Home Journals Articles Updates About
CN
image
收藏切换
Recent advances of PIM kinase and its small-molecule inhibitors
收藏切换
PDF
Kun LI1, Yuan-bo XU2, Wei ZHANG1, Pei-zhi MA1, *
Acta Pharmaceutica Sinica | 2019, 54(11) : 1926 - 1939
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(11): 1926-1939
• Reviews •
Recent advances of PIM kinase and its small-molecule inhibitors
Full
Kun LI1, Yuan-bo XU2, Wei ZHANG1, Pei-zhi MA1, *
Affiliations
  • 1. Department of Pharmacy, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou 450003, China
  • 2. Key Laboratory of Structure-Based Drugs Design and Discovery(Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, China
Published: 2019-11-12 doi: 10.16438/j.0513-4870.2019-0466
Outline
收藏切换

Provirus Integration in Maloney murine leukemia virus (PIM) represents a novel class of unique Ser/Thr kinase, which has been identified to be over-expressed in multiple hematological malignancies and some solid tumors, and the expression quantity correlates with malignant grade and poor prognosis in patients with cancer. PIM kinase plays important roles in regulation of cell proliferation and differentiation through the phosphorylation of its protein substrates, and it has become the emerging target for cancer treatment. A large number of highly active PIM kinase inhibitors have been reported by domestic and foreign research institutions, and the research progress will be summarized according to affiliations in this review.

PIM kinase  /  kinase inhibitor  /  anticancer  /  structure-activity relationship
Kun LI, Yuan-bo XU, Wei ZHANG, Pei-zhi MA. Recent advances of PIM kinase and its small-molecule inhibitors[J]. Acta Pharmaceutica Sinica, 2019 , 54 (11) : 1926 -1939 . DOI: 10.16438/j.0513-4870.2019-0466
Appendix
Less
Year 2019 volume 54 Issue 11
PDF
132
50
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0466
  • Receive Date：2019-06-12
  • Online Date：2026-01-26
  • Published：2019-11-12
Article Data
Affiliations
History
  • Received：2019-06-12
  • Revised：2019-07-22
Funding
Affiliations
    1. Department of Pharmacy, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou 450003, China
    2. Key Laboratory of Structure-Based Drugs Design and Discovery(Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0466
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House