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Application prospect of organoids and 3D-cell models in evaluation of cardiotoxicity of traditional Chinese medicine
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Xin-yan LIU1, 2, Rui SHAO1, 2, Shuang HE1, 2, Yan ZHU1, 2, *
Acta Pharmaceutica Sinica | 2019, 54(11) : 1888 - 1894
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Acta Pharmaceutica Sinica | 2019, 54(11): 1888-1894
• Special Reports: The cardiac safety evaluation and rational use of cardiovascular disease prevention and treatment of Chinese medicine •
Application prospect of organoids and 3D-cell models in evaluation of cardiotoxicity of traditional Chinese medicine
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Xin-yan LIU1, 2, Rui SHAO1, 2, Shuang HE1, 2, Yan ZHU1, 2, *
Affiliations
  • 1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
Published: 2019-11-12 doi: 10.16438/j.0513-4870.2019-0105
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Cardiotoxicity is one of the main causes of failure in new drug development or drug withdrawal from the market. However, current methods for evaluation of drug cardiotoxicity suffer the shortcomings such as low clinical relevance, low reproducibility and lack of high throughput screening capacity. Therefore, there is an urgent need for establishing more accurate and reliable methods for cardiotoxicity evaluation of drugs. As a new generation of drug cardiotoxicity evaluation, cardiac organs in culture retain the biological characteristics and functions of heart cells in the body, and can realistically and accurately respond to the effects of drugs. This article reviews recent progress of in vitro culture of cardiac organs and 3D-cell models, with focuses on application and development potential of cardiac organs for evaluation of cardiotoxicity of traditional Chinese medicine. The advantage and future prospective of such cell- and organ-based models for unique challenges in evaluation of cardiotoxicity of traditional Chinese medicine have been discussed.

traditional Chinese medicine  /  cardiotoxicity  /  two-dimensional cell  /  three-dimensional cell  /  organoid  /  toxicity evaluation technology
Xin-yan LIU, Rui SHAO, Shuang HE, Yan ZHU. Application prospect of organoids and 3D-cell models in evaluation of cardiotoxicity of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2019 , 54 (11) : 1888 -1894 . DOI: 10.16438/j.0513-4870.2019-0105
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Article Info
doi: 10.16438/j.0513-4870.2019-0105
  • Receive Date：2019-02-14
  • Online Date：2026-01-26
  • Published：2019-11-12
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  • Received：2019-02-14
  • Revised：2019-03-28
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    1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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