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Determining the effect of Huangqi on the pharmacokinetics of six different alkaloids from Fuzi in rats by LC-MS
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Yu-ting LIU1, Qie-ying JIANG2, Guo-yong HUANG1, Xu-long CHEN1, Zheng-gen LIAO1, *
Acta Pharmaceutica Sinica | 2019, 54(12) : 2289 - 2295
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Acta Pharmaceutica Sinica | 2019, 54(12): 2289-2295
• Original Articles •
Determining the effect of Huangqi on the pharmacokinetics of six different alkaloids from Fuzi in rats by LC-MS
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Yu-ting LIU1, Qie-ying JIANG2, Guo-yong HUANG1, Xu-long CHEN1, Zheng-gen LIAO1, *
Affiliations
  • 1. Key Laboratory of Modern Preparation of Chinese Materia Medica, Ministry of Education, Nanchang 330004, China
  • 2. Laboratory Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0294
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This study aimed to investigate the influence of combinating Huangqi with Fuzi on the pharmacokinetics of six Aconitum alkaloids, i.e. aconitine (AC), hypaconitine (HA), mesaconitine (MA), benzoylaconine (BAC), benzoylhypaconine (BHA) and benzoylmesaconine (BMA). The plasma concentrations of the drugs were determined by LC-MS for dose response and time dependent curves. The pharmacokinetic parameters were calculated by DAS 3.3, and SPSS 12.0 was used to analyze the differences of main pharmacokinetic parameters between the two groups. Comparing with Fuzi group, the AUC0-t and AUC0-∞ of six alkaloids in Fuzi-Huangqi group was significantly decreased, the CLz/F of six alkaloids except HA was significantly increased; the Cmax was decreased and the tmax was prolonged in 3 monoester alkaloids, and the apparent volume of distribution of BMA and MA (Vz/F) increases. These data indicated that Huangqi can inhibit the absorption of aconite alkaloids, induce the distribution of aconite alkaloids to the whole body, and accelerate the elimination of aconite alkaloids. The animal experiment scheme in this study has been approved by the Experimental Animal Ethics Committee of Jiangxi University of Traditional Chinese Medicine.

Fuzi  /  Huangqi  /  pharmacokinetics  /  LC-MS
Yu-ting LIU, Qie-ying JIANG, Guo-yong HUANG, Xu-long CHEN, Zheng-gen LIAO. Determining the effect of Huangqi on the pharmacokinetics of six different alkaloids from Fuzi in rats by LC-MS[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2289 -2295 . DOI: 10.16438/j.0513-4870.2019-0294
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Year 2019 volume 54 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2019-0294
  • Receive Date：2019-05-17
  • Online Date：2026-01-26
  • Published：2019-12-12
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  • Received：2019-05-17
  • Revised：2019-07-26
Funding
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    1. Key Laboratory of Modern Preparation of Chinese Materia Medica, Ministry of Education, Nanchang 330004, China
    2. Laboratory Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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