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A new furocoumarin from the stems of Clausena lansium
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Xing-yan SUN, Jie MA, Chuang-jun LI, Ji-wu HUANG, Nan WANG, Cang-jie SHEN, Dong-ming ZHANG*
Acta Pharmaceutica Sinica | 2019, 54(12) : 2282 - 2285
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Acta Pharmaceutica Sinica | 2019, 54(12): 2282-2285
• Original Articles •
A new furocoumarin from the stems of Clausena lansium
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Xing-yan SUN, Jie MA, Chuang-jun LI, Ji-wu HUANG, Nan WANG, Cang-jie SHEN, Dong-ming ZHANG*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0545
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One undescribed and two known furocoumarins were isolated from the stems of the Clausena lansium through a series of isolation and purification approaches including HPD-100 macroporous resin column, silica gel, reverse phase C18 and so on. Their structures were determined to be 8-[(2S, 3S, 6E)-2, 3-epoxy-3, 7-dimethyl-oct-6-enyloxy] psoralen (1), 8-(7', 8'-epoxygeranyloxy) psoralen (2) and 8-[(2E)-6-oxo-3, 7-dimethyloct-2-enyloxy] psoralen (3) by spectroscopic methods. Compound 1 is a new furocoumarin. Compound 2 showed cytotoxicity to H460 (IC50=43.94 μmol·L-1) and compound 3 showed cytotoxicity to HeLa (33.76 μmol·L-1) through the cytotoxic tests against five human cancer cell lines (H460, H7402, HCT-8, HeLa and MCF-7) for all compounds.

Clausena lansium  /  chemical constituents  /  furocoumarin  /  cytotoxicity
Xing-yan SUN, Jie MA, Chuang-jun LI, Ji-wu HUANG, Nan WANG, Cang-jie SHEN, Dong-ming ZHANG. A new furocoumarin from the stems of Clausena lansium[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2282 -2285 . DOI: 10.16438/j.0513-4870.2019-0545
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doi: 10.16438/j.0513-4870.2019-0545
  • Receive Date：2019-07-10
  • Online Date：2026-01-26
  • Published：2019-12-12
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  • Received：2019-07-10
  • Revised：2019-09-06
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    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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