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Quality control of Shuanghuanglian preparations using an effect-constituent index
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Hui ZHANG, Si-yu LI, Hong-ling FENG, Mu-rui LI, Zhi-dong PEI*, Ting-guo KANG*
Acta Pharmaceutica Sinica | 2019, 54(12) : 2149 - 2154
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Acta Pharmaceutica Sinica | 2019, 54(12): 2149-2154
• Special Reports: Biological Evaluation and Precise Control for the Quality of Traditional Chinese Medicines •
Quality control of Shuanghuanglian preparations using an effect-constituent index
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Hui ZHANG, Si-yu LI, Hong-ling FENG, Mu-rui LI, Zhi-dong PEI*, Ting-guo KANG*
Affiliations
  • College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0449
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We established a quality evaluation method for Shuanghuanglian preparations based on an effect-constituent index (ECI), which is guided by the clinical efficacy of Shuanghuanglian and a dose-efficacy correlation. An HPLC method was used to establish the quantitative fingerprint of Shuanghuanglian from different manufacturers and to determine the content of 10 fingerprint components, including baicalin, chlorogenic acid, forsythin, galuteolin, wogonin, forsythoside A, luteolin, caffeic acid, baicalein, and scutellarin. Using Staphylococcus aureus as biological model, the potency of Shuanghuanglian preparations was determined by antibiotic microbial assay. Using the method of PLC-DA, the efficacious antibacterial components were screened by "dose-efficacy" correlation analysis. According to the antibacterial potency and content of the antibacterial ingredients, combined with the method of the custom weight coefficient, ECI was calculated and verified. The results show that the antibacterial ECI can facilitate evaluation of the efficacy of Shuanghuanglian based on the composition of its contents, providing a new method for the quality control of traditional Chinese medicine.

Shuanghuanglian preparation  /  effect-constituent index  /  antibacterial potency  /  quantitative fingerprint chromatogram  /  quality control
Hui ZHANG, Si-yu LI, Hong-ling FENG, Mu-rui LI, Zhi-dong PEI, Ting-guo KANG. Quality control of Shuanghuanglian preparations using an effect-constituent index[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2149 -2154 . DOI: 10.16438/j.0513-4870.2019-0449
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doi: 10.16438/j.0513-4870.2019-0449
  • Receive Date：2019-09-05
  • Online Date：2026-01-26
  • Published：2019-12-12
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  • Received：2019-09-05
  • Revised：2019-11-10
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    College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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