Home Journals Articles Updates About
CN
image
收藏切换
Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology
收藏切换
PDF
Qi-cai YIN1, 2, Cong-cong CHEN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Acta Pharmaceutica Sinica | 2019, 54(12) : 2296 - 2302
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(12): 2296-2302
• Original Articles •
Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology
Full
Qi-cai YIN1, 2, Cong-cong CHEN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0435
Outline
收藏切换

To analyze the chemical profile of Radix Bupleuri-Radix Paeoniae Alba in the serum, after oral absorption of the herbal pair, we used UPLC-QE-Orbitrap-MS technique and Compound Discover 2.0 software to compare the components in the extracts, and drug-containing serum. The map, based on the precise molecular weight and secondary fragment information given by the mass spectrometry, combined with the reference substance and reference information for, finding the chemical components in the blood after oral administration of the herbal pair in the rats. Animal experimentation was approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. The results showed that a total of 55 components were detected in the serum, of which 16 were prototype components and 39 were metabolites of prototype components. UPLC-QE-Orbitrap-MS allows quick, accurate and comprehensive analysis of the blood components of the herb pair after oral administration. This preliminary study of the chemical components in the blood after herb pair ingestion provides a basis for the subsequent research on the pharmacodynamics and drug-drug interactions.

Radix Bupleuri  /  Radix Paeoniae Alba  /  serum pharmacochemistry  /  UPLC-QE-Orbitrap-MS  /  prototype component  /  metabolite
Qi-cai YIN, Cong-cong CHEN, Jun-sheng TIAN, Xiao-xia GAO, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2296 -2302 . DOI: 10.16438/j.0513-4870.2019-0435
Appendix
Less
Year 2019 volume 54 Issue 12
PDF
142
53
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0435
  • Receive Date：2019-06-02
  • Online Date：2026-01-26
  • Published：2019-12-12
Article Data
Affiliations
History
  • Received：2019-06-02
  • Revised：2019-07-08
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0435
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House