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Post-translational modifications of proteins and cancer immunotherapy
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Jing JIN, Ming JI, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2019, 54(10) : 1711 - 1717
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Acta Pharmaceutica Sinica | 2019, 54(10): 1711-1717
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Post-translational modifications of proteins and cancer immunotherapy
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Jing JIN, Ming JI, Xiao-guang CHEN*
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  • State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0695
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Post-translational modifications (PTMs) of proteins is an important mode of protein function regulation, which is essential for the structure and function of proteins under physiological and pathological conditions, and the types of modifications is wide. Cancer immunotherapy refers to an effective method for cancer treatment by activating or normalizing disabled immune cells. In recent years, researchers have found that many types of PTM are involved in the process of proliferation, activation and metabolic reprogramming of immune cells in cancer microenvironment, and may affect the efficacy of cancer immunotherapy. Therefore, this article reviews the effects of several different PTMs on immune cells in cancer microenvironment, and aims to provide new ideas for cancer immunotherapy.

post-translational modifications of proteins  /  cancer  /  cancer microenvironment  /  cancer immuno-therapy
Jing JIN, Ming JI, Xiao-guang CHEN. Post-translational modifications of proteins and cancer immunotherapy[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1711 -1717 . DOI: 10.16438/j.0513-4870.2019-0695
Year 2019 volume 54 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2019-0695
  • Receive Date:2019-08-29
  • Online Date:2026-01-26
  • Published:2019-10-12
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  • Received:2019-08-29
  • Revised:2019-09-05
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    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
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占总种数比例
Percentage of
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Genus
种数
Number of
species
占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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