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Research advancement of succinyl-CoA transferase SCOT in tumor metabolism
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Zhi-hui ZHANG, Qing-hua WANG, Ming JI, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2019, 54(10) : 1831 - 1836
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Acta Pharmaceutica Sinica | 2019, 54(10): 1831-1836
• Reviews •
Research advancement of succinyl-CoA transferase SCOT in tumor metabolism
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Zhi-hui ZHANG, Qing-hua WANG, Ming JI, Xiao-guang CHEN*
Affiliations
  • State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0671
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In recent years, the role of ketone body metabolism in tumor growth, invasion and metastasis has attracted much attention. Succinyl-CoA transferase (SCOT) is a key enzyme in the metabolism of ketone bodies. Its function is to transfer the coenzyme A group of succinyl-CoA to acetoacetate and catalyze the formation of acetoacetyl-CoA, which is the first rate-limiting step in ketone metabolism. Then acetoacetyl-CoA further breaks into two molecules of acetyl-CoA and enters the tricarboxylic acid cycle. Studies have shown that SCOT is highly expressed in a variety of tumors, and is closely related to tumor progression and prognosis of patients, which makes SCOT a potential marker for clinical diagnosis and prognosis evaluation; in addition, inhibition of SCOT activity can hinder the metabolism of ketone bodies in tumor cells, that is, reduce the production of ATP, thereby inhibiting tumor growth, proliferation, invasion and metastasis. This review aims to explore the important role of SCOT in metabolic pathways and its relationship with tumorigenesis and development, and to provide new ideas for exploring tumor metabolism and targeting molecular drugs.

ketone body  /  ketolysis  /  succinyl-CoA transferase  /  tumor
Zhi-hui ZHANG, Qing-hua WANG, Ming JI, Xiao-guang CHEN. Research advancement of succinyl-CoA transferase SCOT in tumor metabolism[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1831 -1836 . DOI: 10.16438/j.0513-4870.2019-0671
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doi: 10.16438/j.0513-4870.2019-0671
  • Receive Date：2019-08-22
  • Online Date：2026-01-26
  • Published：2019-10-12
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  • Received：2019-08-22
  • Revised：2019-09-18
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    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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