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Effects of Guilingji on Kidney-Yang deficiency syndrome in rats based on serum metabolomics
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Ke DU1, 2, Xiao-xia GAO1, Yan FENG1, 2, Bin ZHANG3, Pei-yi Wang3, Xue-mei QIN1, *
Acta Pharmaceutica Sinica | 2019, 54(8) : 1476 - 1483
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Acta Pharmaceutica Sinica | 2019, 54(8): 1476-1483
• Original Articles •
Effects of Guilingji on Kidney-Yang deficiency syndrome in rats based on serum metabolomics
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Ke DU1, 2, Xiao-xia GAO1, Yan FENG1, 2, Bin ZHANG3, Pei-yi Wang3, Xue-mei QIN1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Shanxi Guangyuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2019-0310
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This study aimed to address the protective role of Guilingji (GLJ) against hydrocortisone-induced Kidney-Yang deficiency syndrome in rats with metabolites in serum, and explore its regulative approaches. KidneyYang deficiency syndrome rat model was constructed by high-dose injection of hydrocortisone. Rats were randomly divided into 6 groups:control group, model group, positive (Jinkui Shenqi Wan) group and low, medium, or highdose group of GLJ for continuous administration over 30 days. The efficacy of GLJ was evaluated with traditional pharmacodynamic indicators (body weight, behavioral indicators, and biochemical parameters) after the model was replicated successfully. Animal experimentation was approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. Serum metabolic profiles obtained by UHPLC-Q Exactive Orbitrap-MS were used to explore metabolic regulation mechanism of GLJ. The results showed that GLJ could significantly improve Kidney-Yang deficiency syndrome. Pathway analysis showed that leucine-isoleucine metabolism, ether ester metabolism, and bile acid metabolism were the main pathways, with the main mechanism of action involving energy balance, intestinal homeostasis and immune function.

Guilingji  /  Kidney-Yang deficiency syndrome  /  serum  /  metabolomics  /  pathway analysis
Ke DU, Xiao-xia GAO, Yan FENG, Bin ZHANG, Pei-yi Wang, Xue-mei QIN. Effects of Guilingji on Kidney-Yang deficiency syndrome in rats based on serum metabolomics[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1476 -1483 . DOI: 10.16438/j.0513-4870.2019-0310
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Article Info
doi: 10.16438/j.0513-4870.2019-0310
  • Receive Date：2019-04-22
  • Online Date：2026-01-26
  • Published：2019-08-12
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  • Received：2019-04-22
  • Revised：2019-05-16
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Shanxi Guangyuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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