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Network pharmacology-based study on mechanisms of antipyretic action of Pueraria radix
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Bing-tao LI1, Xing-ying ZHAI1, Jia LI2, Jun TU1, Qi-yun ZHANG1, Guo-liang XU1, Li-ping HUANG2, Feng SHAO2, Wei-feng ZHU2, Rong-hua LIU2, *
Acta Pharmaceutica Sinica | 2019, 54(8) : 1409 - 1416
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Acta Pharmaceutica Sinica | 2019, 54(8): 1409-1416
• Original Articles •
Network pharmacology-based study on mechanisms of antipyretic action of Pueraria radix
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Bing-tao LI1, Xing-ying ZHAI1, Jia LI2, Jun TU1, Qi-yun ZHANG1, Guo-liang XU1, Li-ping HUANG2, Feng SHAO2, Wei-feng ZHU2, Rong-hua LIU2, *
Affiliations
  • 1. Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of TCM, Nanchang 330004, China
  • 2. School of Pharmacy, Jiangxi University of TCM, Nanchang 330004, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2018-1098
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This study was designed to explore the antipyretic mechanism of Pueraria radix. The method of network pharmacology was used to determine the known ingredients corresponding to Pueraria radix, predict the drug-related gene/protein targets, and analyze the interplay between key ingredients and targets. Biological Information Annotation Databases (DAVID) was used to enrich the biological processes and pathways. The result of network analysis was validated by molecular docking. It was found that 49 active ingredients of Pueraria radix not only regulate 21 targets (e.g. PTGS2, EGFR), but also affect 11 biological processes (e.g. oxidation-reduction process, prostaglandin synthesis, positive regulation of fever generation and inflammatory response) and 7 metabolic pathways (arachidonic acid metabolism, serotonergic synapse and HIF-1, et al). Molecular docking results showed that more than 65% of the active ingredients could be well docked with key targets, and the relevant literatures indicated that the active components could inhibit the expression of PTGS2, which means the result has a high reliability. These results indicated that Pueraria radix may carry its pyretic action via a "multi-ingredients-multitargets-multi-pathways" mode, which provides a scientific basis for further research and drug development.

Pueraria radix  /  fever  /  network pharmacology  /  molecular docking  /  biology process  /  pathway analysis
Bing-tao LI, Xing-ying ZHAI, Jia LI, Jun TU, Qi-yun ZHANG, Guo-liang XU, Li-ping HUANG, Feng SHAO, Wei-feng ZHU, Rong-hua LIU. Network pharmacology-based study on mechanisms of antipyretic action of Pueraria radix[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1409 -1416 . DOI: 10.16438/j.0513-4870.2018-1098
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Article Info
doi: 10.16438/j.0513-4870.2018-1098
  • Receive Date：2018-12-09
  • Online Date：2026-01-26
  • Published：2019-08-12
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History
  • Received：2018-12-09
  • Revised：2019-01-04
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Affiliations
    1. Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of TCM, Nanchang 330004, China
    2. School of Pharmacy, Jiangxi University of TCM, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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