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Advances in chemical synthesis of dual inhibitors of HIV integrase and ribonuclease H
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Jia-xiong KANG1, 2, Jiang ZHU2, Ai-xiu LI1, 3, *, Yu-rui JIN1
Acta Pharmaceutica Sinica | 2019, 54(8) : 1392 - 1401
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Acta Pharmaceutica Sinica | 2019, 54(8): 1392-1401
• Reviews •
Advances in chemical synthesis of dual inhibitors of HIV integrase and ribonuclease H
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Jia-xiong KANG1, 2, Jiang ZHU2, Ai-xiu LI1, 3, *, Yu-rui JIN1
Affiliations
  • 1. Drug Design Laboratory of the Basic Courses Department, Logistics University of PAP, Tianjin 300309, China
  • 2. Department of Health Service, Logistics University of PAP, Tianjin 300309, China
  • 3. Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300309, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2019-0295
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Antiretroviral therapy has been used for treating AIDS with 31 single-target anti-HIV drugs currently on market. Searching for safe and effective of novel anti-HIV drugs remains a challenge worldwide. Multi-targets single-structure compounds referred to as designed multiple ligands (DMLs) have become a hot topic of producing anti-HIV drugs recently due to reduction in the likelihood of drug resistance, simplified dosing and improved patient adherence. Integrase (IN) and ribonuclease H (RNase H) are two indispensable enzymes in HIV republication, therefore are two important targets for developing anti-HIV drugs. Recently, diverse dual inhibitors of HIV IN and RNase H (IN/RNase H) have been developed via rational drug design and screening. This review summarizes the advances in chemically synthesized dual inhibitors of HIV IN/RNase H to provide the information for developing multi-targets anti-HIV drugs.

human immunodeficiency virus  /  integrase  /  ribonuclease H  /  dual inhibitors
Jia-xiong KANG, Jiang ZHU, Ai-xiu LI, Yu-rui JIN. Advances in chemical synthesis of dual inhibitors of HIV integrase and ribonuclease H[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1392 -1401 . DOI: 10.16438/j.0513-4870.2019-0295
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Year 2019 volume 54 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2019-0295
  • Receive Date：2019-04-22
  • Online Date：2026-01-26
  • Published：2019-08-12
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History
  • Received：2019-04-22
  • Revised：2019-05-22
Funding
Affiliations
    1. Drug Design Laboratory of the Basic Courses Department, Logistics University of PAP, Tianjin 300309, China
    2. Department of Health Service, Logistics University of PAP, Tianjin 300309, China
    3. Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300309, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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