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Progress in research of the structure and function of Elabela/APJ signal
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Hui-ling MAO1, Chun-mei WANG2, Ru-min ZHANG2, Jing CHEN2, *
Acta Pharmaceutica Sinica | 2019, 54(7) : 1174 - 1178
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Acta Pharmaceutica Sinica | 2019, 54(7): 1174-1178
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Progress in research of the structure and function of Elabela/APJ signal
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Hui-ling MAO1, Chun-mei WANG2, Ru-min ZHANG2, Jing CHEN2, *
Affiliations
  • 1. College of Life Sciences, Qufu Normal University, Qufu 273165, China
  • 2. Institute of Neurobiology, Jining Medical College, Jining 272000, China
Published: 2019-07-12 doi: 10.16438/j.0513-4870.2019-0029
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Elabelas/Toddlers belong to a group of endogenous active peptides recently discovered from zebrafish. The sequences of these peptides have 25% homology to Apelin. These peptides regulate physiological functions of organisms through putative protein receptors related to the angiotensin receptor AT1 (APJ). Functional roles of Elabela include early embryonic development, angiogenesis, fluid homeostasis, and feeding or dietary behavior control. Elabela also participates in the development of many diseases, such as heart failure, preeclampsia, acute kidney injury, hypertension, and diabetes. Increasingly, studies have shown that Elabela/APJ signaling can promote normal development of early embryos, including differentiation of mesoderm and endoderm, and formation of cardiac morphology and function. At the same time, the signaling can also promote angiogenesis or migration and proliferation of tumor cells. Here we describe the molecular structure, biological characteristics, functions and application prospects of Elabela/APJ signaling.

elabela  /  APJ  /  structure  /  function  /  multiple diseases
Hui-ling MAO, Chun-mei WANG, Ru-min ZHANG, Jing CHEN. Progress in research of the structure and function of Elabela/APJ signal[J]. Acta Pharmaceutica Sinica, 2019 , 54 (7) : 1174 -1178 . DOI: 10.16438/j.0513-4870.2019-0029
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Year 2019 volume 54 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2019-0029
  • Receive Date：2019-01-09
  • Online Date：2026-01-26
  • Published：2019-07-12
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  • Received：2019-01-09
  • Revised：2019-03-01
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    1. College of Life Sciences, Qufu Normal University, Qufu 273165, China
    2. Institute of Neurobiology, Jining Medical College, Jining 272000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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