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Progress in characteristics and application of olfactory bulbectomy animal model
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Yun-feng ZHOU, Xue TAO, Li-sha WANG, Meng-di ZHANG, Zhi WANG, Xin-min LIU, Qi CHANG*
Acta Pharmaceutica Sinica | 2019, 54(7) : 1157 - 1165
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Acta Pharmaceutica Sinica | 2019, 54(7): 1157-1165
• Reviews •
Progress in characteristics and application of olfactory bulbectomy animal model
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Yun-feng ZHOU, Xue TAO, Li-sha WANG, Meng-di ZHANG, Zhi WANG, Xin-min LIU, Qi CHANG*
Affiliations
  • Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Published: 2019-07-12 doi: 10.16438/j.0513-4870.2018-1043
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In rodents, bilateral olfactory bulbectomy (OBX) results in a series of changes in behaviors and neurobiology, similar to the clinical symptoms of depression in patients. These changes can be reversed by chronic but not acute treatment of antidepressants. Owing to the face, construct and predictive validities, the OBX model has been used to investigate the mechanisms of depression, screen for antidepressants, and reveal the mechanism of drug action. In addition, there are certain features in OBX animals resembling those of patients with Alzheimer's disease (AD), including the impaired learning and memory ability and the accumulation of amyloid-β protein (Aβ). In this review, we present the association between olfaction and depression or AD, the surgical procedure of OBX, the behavioral features of OBX animals, the abnormal changes in cortex and hippocampus, and the application of this model for studying depression and AD. These lines of information are important for the development of antidepressant and anti-dementia drugs using this model.

olfactory bulbectomy  /  animal model  /  behavioral characteristic  /  neurobiochemistry  /  depression  /  Alzheimer's disease
Yun-feng ZHOU, Xue TAO, Li-sha WANG, Meng-di ZHANG, Zhi WANG, Xin-min LIU, Qi CHANG. Progress in characteristics and application of olfactory bulbectomy animal model[J]. Acta Pharmaceutica Sinica, 2019 , 54 (7) : 1157 -1165 . DOI: 10.16438/j.0513-4870.2018-1043
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doi: 10.16438/j.0513-4870.2018-1043
  • Receive Date：2018-11-19
  • Online Date：2026-01-26
  • Published：2019-07-12
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  • Received：2018-11-19
  • Revised：2019-01-03
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    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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