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Investigations of solid states for flavonoids from traditional Chinese medicine
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Yan-ming XIA1, Hui CHEN1, Tian-jian YE3, Jian-jun ZHANG2, Yuan GAO1, *
Acta Pharmaceutica Sinica | 2019, 54(7) : 1190 - 1199
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Acta Pharmaceutica Sinica | 2019, 54(7): 1190-1199
• Reviews •
Investigations of solid states for flavonoids from traditional Chinese medicine
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Yan-ming XIA1, Hui CHEN1, Tian-jian YE3, Jian-jun ZHANG2, Yuan GAO1, *
Affiliations
  • 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 3. Zhejiang Yongning Pharmaceutical Co. Ltd., Taizhou 318020, China
Published: 2019-07-12 doi: 10.16438/j.0513-4870.2019-0093
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Flavonoids are important active ingredients in traditional Chinese medicine. However, their applications for the pharmaceutical use are greatly limited by low oral bioavailability due to poor aqueous solubility. The study of pharmaceutical crystallography is a potential approach to solve many problems of poor solubility. Research progress of flavonoid compounds in pharmaceutical crystallography field was reviewed from following aspects:polymorphism, cocrystal, amorphous/co-amorphous and nanocrystals. The information provided here is expected to serve as a reference for the applications of pharmaceutical crystallography in the poorly soluble components of traditional Chinese medicine.

flavonoids  /  traditional Chinese medicine  /  polymorphism  /  cocrystal
Yan-ming XIA, Hui CHEN, Tian-jian YE, Jian-jun ZHANG, Yuan GAO. Investigations of solid states for flavonoids from traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2019 , 54 (7) : 1190 -1199 . DOI: 10.16438/j.0513-4870.2019-0093
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Article Info
doi: 10.16438/j.0513-4870.2019-0093
  • Receive Date：2019-01-28
  • Online Date：2026-01-26
  • Published：2019-07-12
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History
  • Received：2019-01-28
  • Revised：2019-04-15
Funding
Affiliations
    1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
    3. Zhejiang Yongning Pharmaceutical Co. Ltd., Taizhou 318020, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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