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Exploration of non-clinical pharmacodynamics evaluation system of amyotrophic lateral sclerosis
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Yu-chen PENG1, Xin-hong FENG2, Yong ZHANG1, Long-jian HUANG1, Chun-yang ZHAO3, Xiao-liang WANG1, Qing-li WANG3, *, Ying PENG1, *
Acta Pharmaceutica Sinica | 2019, 54(5) : 788 - 800
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Acta Pharmaceutica Sinica | 2019, 54(5): 788-800
• Reviews •
Exploration of non-clinical pharmacodynamics evaluation system of amyotrophic lateral sclerosis
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Yu-chen PENG1, Xin-hong FENG2, Yong ZHANG1, Long-jian HUANG1, Chun-yang ZHAO3, Xiao-liang WANG1, Qing-li WANG3, *, Ying PENG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Department of Neurology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
  • 3. Center for Drug Evaluation, National Medical Product Administration, Beijing 100038, China
Published: 2019-05-12 doi: 10.16438/j.0513-4870.2018-1141
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Amyotrophic lateral sclerosis (ALS) is among the most common type of motor neuron diseases, and its pathogenesis remains unclear. In recent years, our understanding of the genetic basis of ALS has led to the development of various ALS disease models, which allow for screening of ALS-related drugs and treatment methods. This review focuses on the research progress of ALS, summarizes the systems of commonly used experi mental animal models, including transgenic animals, gene knockout approaches and autonomous animal models, points to the problems needing attention in standardized ALS non-clinical research, and proposes the criteria for selection of standardized R&D model.

amyotrophic lateral sclerosis  /  non-clinical pharmacodynamics  /  superoxide dismutase 1  /  animal model
Yu-chen PENG, Xin-hong FENG, Yong ZHANG, Long-jian HUANG, Chun-yang ZHAO, Xiao-liang WANG, Qing-li WANG, Ying PENG. Exploration of non-clinical pharmacodynamics evaluation system of amyotrophic lateral sclerosis[J]. Acta Pharmaceutica Sinica, 2019 , 54 (5) : 788 -800 . DOI: 10.16438/j.0513-4870.2018-1141
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Article Info
doi: 10.16438/j.0513-4870.2018-1141
  • Receive Date：2018-12-24
  • Online Date：2026-01-26
  • Published：2019-05-12
Article Data
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History
  • Received：2018-12-24
  • Revised：2019-01-08
Funding
Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Department of Neurology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
    3. Center for Drug Evaluation, National Medical Product Administration, Beijing 100038, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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