Home Journals Articles Updates About
CN
image
收藏切换
Advances and applications of lysine acetylation
收藏切换
PDF
Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA*
Acta Pharmaceutica Sinica | 2019, 54(5) : 778 - 787
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(5): 778-787
• Reviews •
Advances and applications of lysine acetylation
Full
Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-05-12 doi: 10.16438/j.0513-4870.2019-0014
Outline
收藏切换

Protein acetylation is a process of adding an acetyl group to a protein lysine residue with the help of acetyltransferase, which is a pivotal protein post-translational modification linking acetyl-CoA metabolism and cell signal transduction. Recently, the development of mass spectrometry has deepened our understanding of lysine acetylation. Lysine acetylation is involved in many processes such as gene transcription, protein degradation, cellular metabolism, and stress response, which affects biological processes by regulating protein interactions, activity, stability and localization. Protein acetylation is widely happened and plays important regulatory roles in a diversity of human diseases such as metabolic diseases, tumors and cardiovascular diseases. Besides, deacetylase inhibitors have displayed a great potential in the treatment of various diseases especially tumors and metabolic associated diseases. In this review, we summarized the advances and application of acetylation, and discussed the remaining problems in this area.

acetylation  /  metabolism  /  protein modification  /  translational
Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA. Advances and applications of lysine acetylation[J]. Acta Pharmaceutica Sinica, 2019 , 54 (5) : 778 -787 . DOI: 10.16438/j.0513-4870.2019-0014
Appendix
Less
Year 2019 volume 54 Issue 5
PDF
104
40
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0014
  • Receive Date：2019-01-05
  • Online Date：2026-01-26
  • Published：2019-05-12
Article Data
Affiliations
History
  • Received：2019-01-05
  • Revised：2019-03-05
Funding
Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0014
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House