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Phosphoglycerate kinase 1 and cancer
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Yu-ying WANG1, Xin QI1, Jing LI1, 2, *
Acta Pharmaceutica Sinica | 2019, 54(6) : 978 - 983
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Acta Pharmaceutica Sinica | 2019, 54(6): 978-983
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Phosphoglycerate kinase 1 and cancer
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Yu-ying WANG1, Xin QI1, Jing LI1, 2, *
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • 2. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
Published: 2019-06-12 doi: 10.16438/j.0513-4870.2018-1101
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Phosphoglycerate kinase 1 (PGK1) is a key metabolic enzyme in the glycolysis pathway, which catalyzes the transfer of 1, 3-bisphosphoglycerate (1, 3-BPG) to 3-phosphoglycerate (3-PG) with ATP production. Over-expression of PGK1 has been observed in many types of malignance. Besides as a metabolic enzyme, PGK1 can also act as a protein kinase, which promotes the development and progression of tumors and correlates with chemoradiotherapy resistance and poor survival of cancer patients by regulating tumor cell metabolism. Functions of PGK1 were summarized in this article to provide theoretical basis for PGK1-targeting drug development.

phosphoglycerate kinase 1  /  glycolysis  /  cancer
Yu-ying WANG, Xin QI, Jing LI. Phosphoglycerate kinase 1 and cancer[J]. Acta Pharmaceutica Sinica, 2019 , 54 (6) : 978 -983 . DOI: 10.16438/j.0513-4870.2018-1101
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Article Info
doi: 10.16438/j.0513-4870.2018-1101
  • Receive Date：2018-12-11
  • Online Date：2026-01-26
  • Published：2019-06-12
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History
  • Received：2018-12-11
  • Revised：2019-01-11
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Affiliations
    1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
    2. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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