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Research progress of drug delivery system with "gatekeeper"
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Jia ZHANG1, Ting ZHAO1, Jie-ning DUN1, Ming-xian SUN1, Rong-rong HUANG1, Bai XIANG1, *, Jing BAI2, *, De-ying CAO1
Acta Pharmaceutica Sinica | 2019, 54(6) : 1017 - 1025
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Acta Pharmaceutica Sinica | 2019, 54(6): 1017-1025
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Research progress of drug delivery system with "gatekeeper"
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Jia ZHANG1, Ting ZHAO1, Jie-ning DUN1, Ming-xian SUN1, Rong-rong HUANG1, Bai XIANG1, *, Jing BAI2, *, De-ying CAO1
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. Department of Pharmacy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Published: 2019-06-12 doi: 10.16438/j.0513-4870.2019-0134
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The drug delivery system with "gatekeeper" is designed to achieve a stable entrapment state of the payload under normal physiological conditions through the gatekeepers. With tumor microenvironment or stimulation of exogenous factors, the gatekeeper is detached or altered to promote the responsive release of the drug. In this paper, we focus on applications of stimuli-responsive linkages and stimuli-responsive groups, and review research progresses of drug delivery system with "gatekeeper" developed over the past 10 years.

gatekeeper  /  drug delivery system  /  microenvironment  /  stimuli-responsive  /  tumor therapy
Jia ZHANG, Ting ZHAO, Jie-ning DUN, Ming-xian SUN, Rong-rong HUANG, Bai XIANG, Jing BAI, De-ying CAO. Research progress of drug delivery system with "gatekeeper"[J]. Acta Pharmaceutica Sinica, 2019 , 54 (6) : 1017 -1025 . DOI: 10.16438/j.0513-4870.2019-0134
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Year 2019 volume 54 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2019-0134
  • Receive Date：2019-02-22
  • Online Date：2026-01-26
  • Published：2019-06-12
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History
  • Received：2019-02-22
  • Revised：2019-04-02
Funding
Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. Department of Pharmacy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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