Home Journals Articles Updates About
CN
image
收藏切换
Advance in biosynthesis of plant-derived oleanane type triterpenoids such as Polygala saponins with catalysis by cytochrome P450s
收藏切换
PDF
Fu-sheng ZHANG1, *, Ran-ran KONG1, 2, Tong-yao CHEN1, Qian-yu WANG1, 2, Xue-mei QIN1, Chen-hui DU3, Cun-gen MA3, *
Acta Pharmaceutica Sinica | 2019, 54(6) : 1000 - 1009
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(6): 1000-1009
• Reviews •
Advance in biosynthesis of plant-derived oleanane type triterpenoids such as Polygala saponins with catalysis by cytochrome P450s
Full
Fu-sheng ZHANG1, *, Ran-ran KONG1, 2, Tong-yao CHEN1, Qian-yu WANG1, 2, Xue-mei QIN1, Chen-hui DU3, Cun-gen MA3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Shanxi University of Chinese Medicine, Taiyuan 030024, China
Published: 2019-06-12 doi: 10.16438/j.0513-4870.2019-0187
Outline
收藏切换

Plant-derived triterpenoids constitute a large and structurally diverse class of natural products with various implications in industrial and pharmaceutical uses. The oleanane type triterpenoids are widely known for their pharmacological and/or biological activities. The biosynthesis pathway of oleanane triterpenoids is divided into three stages:precursor supply, skeleton synthesis, and terpenoids synthesis. Plant cytochrome P450 monooxygenases enzymes (P450s) are involved in the synthesis and diversification of natural products, and are responsible for other modifications of terpenoids, such as formation of triterpenoids. P450s-catalyzed structural modification prior to glycosylation is crucial for diversification and functionalization of triterpenoid scaffolds. In this paper, the catalyses of P450s on β-amyrin and oleanolic acid in oleanane type triterpenoid saponins biosynthesis were reviewed. Presenegenin is a major aglycon of Polygala saponins. The CYP716A249 in Polygala tenuifolia was used as an example to other P450s participating in the possible biosynthetic pathways of presenegenin. These results provide references for elucidation of the biosynthesis pathways of plant-derived oleanane type triterpenoids.

cytochrome P450 monooxygenase  /  plant-derived triterpenoid  /  oleanane type triterpenoid saponin  /  Polygala saponin  /  biosynthesis
Fu-sheng ZHANG, Ran-ran KONG, Tong-yao CHEN, Qian-yu WANG, Xue-mei QIN, Chen-hui DU, Cun-gen MA. Advance in biosynthesis of plant-derived oleanane type triterpenoids such as Polygala saponins with catalysis by cytochrome P450s[J]. Acta Pharmaceutica Sinica, 2019 , 54 (6) : 1000 -1009 . DOI: 10.16438/j.0513-4870.2019-0187
Appendix
Less
Year 2019 volume 54 Issue 6
PDF
125
52
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0187
  • Receive Date：2019-03-20
  • Online Date：2026-01-26
  • Published：2019-06-12
Article Data
Affiliations
History
  • Received：2019-03-20
  • Revised：2019-04-03
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Shanxi University of Chinese Medicine, Taiyuan 030024, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0187
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House