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Medications regulate autophagy for treatment of Alzheimer's disease
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Cheng-yong TAN1, Hui-zhen TIAN1, Huang KUANG1, Fen-fang HONG2, *, Shu-long YANG1, *
Acta Pharmaceutica Sinica | 2019, 54(6) : 984 - 990
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Acta Pharmaceutica Sinica | 2019, 54(6): 984-990
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Medications regulate autophagy for treatment of Alzheimer's disease
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Cheng-yong TAN1, Hui-zhen TIAN1, Huang KUANG1, Fen-fang HONG2, *, Shu-long YANG1, *
Affiliations
  • 1. College of Basic Medicine, Nanchang University, Nanchang 330031, China
  • 2. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China
Published: 2019-06-12 doi: 10.16438/j.0513-4870.2018-1107
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Alzheimer's disease (AD) is characterized clinically as irreversible cognitive dysfunction. Although a significant progress has been made in the study of AD pathogenesis, the effective measures to block AD progress have not been satisfactory. Abnormal autophagy is thought to be involved in the pathogenesis of AD, and regulation of autophagy may become a new strategy for AD treatment. Some medicines, which regulate autophagy by mTOR-dependent and independent (Bcl-2/Beclin-1, GSK-3β, and p-AKT) pathways, have shown excellent effects in alleviating AD symptoms. In addition, certain compounds extracted from plants have also been reported to regulate autophagy and prevent AD progression through multiple pathways and multiple targets. This article reviews the recent advances in the regulation of autophagy and AD treatment. It provides a new theoretical basis for clinical treatment of AD.

autophagy  /  Alzheimer's disease  /  plant extract compound  /  medicine
Cheng-yong TAN, Hui-zhen TIAN, Huang KUANG, Fen-fang HONG, Shu-long YANG. Medications regulate autophagy for treatment of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2019 , 54 (6) : 984 -990 . DOI: 10.16438/j.0513-4870.2018-1107
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Article Info
doi: 10.16438/j.0513-4870.2018-1107
  • Receive Date：2018-12-10
  • Online Date：2026-01-26
  • Published：2019-06-12
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  • Received：2018-12-10
  • Revised：2019-01-13
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Affiliations
    1. College of Basic Medicine, Nanchang University, Nanchang 330031, China
    2. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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