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The contribution of Radix Bupleuri-Radix Paeoniae Alba herb pair to Xiaoyaosan based on 1H NMR metabolomics
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Shi-wei ZHU1, 2, Wen-xia GONG1, Cong-cong CHEN1, 2, Qi-cai YIN1, 2, Xiao LI1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Acta Pharmaceutica Sinica | 2019, 54(4) : 720 - 728
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Acta Pharmaceutica Sinica | 2019, 54(4): 720-728
• Original Articles •
The contribution of Radix Bupleuri-Radix Paeoniae Alba herb pair to Xiaoyaosan based on 1H NMR metabolomics
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Shi-wei ZHU1, 2, Wen-xia GONG1, Cong-cong CHEN1, 2, Qi-cai YIN1, 2, Xiao LI1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-04-12 doi: 10.16438/j.0513-4870.2018-1123
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This study explores the antidepressant mechanism of Radix Bupleuri-Radix Paeoniae Alba herb pair and the core role in Xiaoyaosan. The behavioral indicators were used to observe the effects of herb pair, Xiaoyaosan, and a negative control (Xiaoyaosan remove Radix Bupleuri-Radix Paeoniae Alba) on CUMS rats. The body weight, number of crossing and rearing, sugar preference rate were significantly decreased (P < 0.001) and the immobility time of forced swimming test was significantly prolonged (P < 0.01) in the model group. Radix Bupleuri-Radix Paeoniae Alba herb pair has significant antidepressant effect, with the number of crossing in low dose group similar to Xiaoyaosan, while the number of rearing and the sucrose preference rate in high dose group are equivalent to Xiaoyaosan, and the immobility time in high and low-doses group are better than Xiaoyaosan. Animal experimentation was approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. Metabonomics results showed 15 biomarkers related to depression, whereas administering Xiaoyaosan or the herb pair can ameliorate 12 or 8 metabolites respectively, compared to the negative control, which can only ameliorate 6 metabolites. The metabolic pathway analysis showed 5 depression-related pathways. The herb pair and Xiaoyaosan exerted antidepressant effects through common 4 metabolic pathways, while the negative control only exerted effects through 3. In summary, behavioral, metabolomics and metabolic pathway analysis revealed that Radix Bupleuri-Radix Paeoniae Alba plays an important role in the biological effect of Xiaoyaosan.

metabolomics  /  Radix Bupleuri  /  Radix Paeoniae Alba  /  herb pair  /  Xiaoyaosan  /  antidepressant
Shi-wei ZHU, Wen-xia GONG, Cong-cong CHEN, Qi-cai YIN, Xiao LI, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. The contribution of Radix Bupleuri-Radix Paeoniae Alba herb pair to Xiaoyaosan based on 1H NMR metabolomics[J]. Acta Pharmaceutica Sinica, 2019 , 54 (4) : 720 -728 . DOI: 10.16438/j.0513-4870.2018-1123
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Article Info
doi: 10.16438/j.0513-4870.2018-1123
  • Receive Date：2018-12-18
  • Online Date：2026-01-26
  • Published：2019-04-12
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History
  • Received：2018-12-18
  • Revised：2019-01-16
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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