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The concept, core theory and research methods of Chinese medicine quality markers
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Tie-jun ZHANG1, 3, Gang BAI2, Chang-xiao LIU1, 3, *
Acta Pharmaceutica Sinica | 2019, 54(2) : 187 - 196
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Acta Pharmaceutica Sinica | 2019, 54(2): 187-196
Special Reports: The Quality and Quality Markers of Traditional Chinese Medicine
The concept, core theory and research methods of Chinese medicine quality markers
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Tie-jun ZHANG1, 3, Gang BAI2, Chang-xiao LIU1, 3, *
Affiliations
  • 1. National Engineering Laboratory for Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Research Center of Quality Markers of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
  • 2. College of Pharmacy, Nankai University/State Key Laboratory of Medicinal Chemical Biology, Tianjin 300353, China
  • 3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Published: 2019-02-12 doi: 10.16438/j.0513-4870.2018-0912
Outline
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Q-marker is a new concept of quality control for traditional Chinese medicine. Since its introduction in 2016, it has received extensive support and participation from researchers and manufactures of the entire industry. In order to establishing the research level of quality markers, normative research model, we review the proposed core theory and research methods of Chinese medicine quality markers. The definition and scientific connotation of Chinese medicine quality markers are analyzed. The core theories and research methods of quality markers are summarized from five aspects:"effectiveness", "specificity", "transfer and traceability", "compatibility environment" and "measurability" of quality markers. This paper aims to provide useful theoretical and methodological guidance for studying Chinese medicine quality markers.

traditional Chinese medicine  /  quality marker  /  theory  /  research method
Tie-jun ZHANG, Gang BAI, Chang-xiao LIU. The concept, core theory and research methods of Chinese medicine quality markers[J]. Acta Pharmaceutica Sinica, 2019 , 54 (2) : 187 -196 . DOI: 10.16438/j.0513-4870.2018-0912
Year 2019 volume 54 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2018-0912
  • Receive Date:2018-10-09
  • Online Date:2026-01-26
  • Published:2019-02-12
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History
  • Received:2018-10-09
  • Revised:2018-11-13
Affiliations
    1. National Engineering Laboratory for Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Research Center of Quality Markers of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
    2. College of Pharmacy, Nankai University/State Key Laboratory of Medicinal Chemical Biology, Tianjin 300353, China
    3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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