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A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi
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Xiao-tao HOU1, 2, 3, Er-wei HAO2, 3, 4, Zheng-cai DU2, 3, 4, Zhong-shang XIA1, Jia-gang DENG2, 3, *, Tie-jun ZHANG5, Chang-xiao LIU5, *
Acta Pharmaceutica Sinica | 2019, 54(2) : 211 - 221
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Acta Pharmaceutica Sinica | 2019, 54(2): 211-221
• Special Reports: The Quality and Quality Markers of Traditional Chinese Medicine •
A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi
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Xiao-tao HOU1, 2, 3, Er-wei HAO2, 3, 4, Zheng-cai DU2, 3, 4, Zhong-shang XIA1, Jia-gang DENG2, 3, *, Tie-jun ZHANG5, Chang-xiao LIU5, *
Affiliations
  • 1. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China
  • 2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China
  • 3. Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China
  • 4. Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
  • 5. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Published: 2019-02-12 doi: 10.16438/j.0513-4870.2018-0824
Outline
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The quality definition of traditional Chinese medicine (TCM) is a hot area in modern research of TCM. In recent years, the characteristics of one herb with multiple effects have been widely accepted and studied. The typical opposite-effect of herbs is considered as a special part of one herb with multiple effects, and was summarized in this paper. Sanqi was used as an example of opposite-effect herbs for developing the strategies and approaches on the Q-markers. The traditional opposite-effect should be studied by modern pharmacological research methods. The correlation of the chemical components with the opposite effects should be established in order to verify the material basis and evaluate the mechanism including targets and pathways. The unique characteristics of chemical components should be analyzed and defined. Finally, the Q-markers of the opposite effect herb will be confirmed. This paper provides a useful reference for the precise quality control of herbal opposite-effects.

opposite-effect  /  Q-marker  /  Sanqi  /  strategies and approaches
侯小涛, 郝二伟, 杜正彩, 夏中尚, 邓家刚, 张铁军, 刘昌孝. 基于反向功效差异性特点的中药质量标志物研究思路—以三七为例. 药学学报, 2019 , 54 (2) : 211 -221 . DOI: 10.16438/j.0513-4870.2018-0824
Xiao-tao HOU, Er-wei HAO, Zheng-cai DU, Zhong-shang XIA, Jia-gang DENG, Tie-jun ZHANG, Chang-xiao LIU. A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi[J]. Acta Pharmaceutica Sinica, 2019 , 54 (2) : 211 -221 . DOI: 10.16438/j.0513-4870.2018-0824
Year 2019 volume 54 Issue 2
650
321
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Article Info
doi: 10.16438/j.0513-4870.2018-0824
  • Receive Date:2018-09-08
  • Online Date:2026-01-26
  • Published:2019-02-12
Article Data
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History
  • Received:2018-09-08
  • Revised:2018-12-03
Funding
Affiliations
    1. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China
    2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China
    3. Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China
    4. Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
    5. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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