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Phospholipidomics study of Jiegeng Decotion for LPS-induced acute lung injury in mice based on UHPLC-Q-Exactive Orbitrap/MS
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Rui YANG1, 2, Wen-juan QIAN2, 3, Lin-xiu PENG2, 3, Jia XU2, Tong XIE2, Jian-jian JI2, Xiu-qin ZHAN1, *, Jin-jun SHAN1, 2, 3, *
Acta Pharmaceutica Sinica | 2019, 54(1) : 144 - 150
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Acta Pharmaceutica Sinica | 2019, 54(1): 144-150
• ORIGINAL ARTICLES •
Phospholipidomics study of Jiegeng Decotion for LPS-induced acute lung injury in mice based on UHPLC-Q-Exactive Orbitrap/MS
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Rui YANG1, 2, Wen-juan QIAN2, 3, Lin-xiu PENG2, 3, Jia XU2, Tong XIE2, Jian-jian JI2, Xiu-qin ZHAN1, *, Jin-jun SHAN1, 2, 3, *
Affiliations
  • 1. Jiangsu Key Laboratory of Pediatric Respiratory Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. College of Pharmacy, Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System DDS, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0598
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Using the lipidomics method based on UHPLC-Q-Exactive Orbitrap/MS, the change of phospholipid metabolism in lung tissue of mice induced by lipopolysaccharide (LPS)-induced acute lung injury was analyzed to observe the regulation of abnormal lipids by Jiegeng Decoction and to explore the regulation effect of Jiegeng Decoction on LPS-induced acute lung injury. The lung tissue samples from control group, model group, dexamethasone (positive drug) group, and Jiegeng Decoction group were collected and the lipid components of the sample were extracted. All procedures over mice were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of Nanjing University of Chinese Medicine, and the experiments were approved by the Animal Ethics Committee of our university. The lipidomics technique of UHPLC-Q-Exactive Orbitrap/MS was used to study change of phospholipids in lung tissue of each group. LPS induced acute lung injury in mice with metabolic abnormalities of phospholipids, the specific performance of the PC was significantly upregulated, phosphatidyl ethanolamine (PE), phosphatidyl glycerol (PG), phosphatidyl serine (PS), phosphatidylinositol (PI) and other metabolic disorders, Jiegeng Decoction have a certain role in these phospholipids. LPS-induced acute lung injury caused disturbances of phospholipid in vivo, and Jiegeng Decoction regulates metabolic phospholipids.

UHPLC-Q-Exactive Orbitrap/MS  /  lipopolysaccharide  /  acute lung injury  /  Jiegeng Decoction  /  phospholipidomics
Rui YANG, Wen-juan QIAN, Lin-xiu PENG, Jia XU, Tong XIE, Jian-jian JI, Xiu-qin ZHAN, Jin-jun SHAN. Phospholipidomics study of Jiegeng Decotion for LPS-induced acute lung injury in mice based on UHPLC-Q-Exactive Orbitrap/MS[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 144 -150 . DOI: 10.16438/j.0513-4870.2018-0598
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Article Info
doi: 10.16438/j.0513-4870.2018-0598
  • Receive Date：2018-06-30
  • Online Date：2026-01-26
  • Published：2019-01-12
Article Data
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History
  • Received：2018-06-30
  • Revised：2018-08-18
Funding
Affiliations
    1. Jiangsu Key Laboratory of Pediatric Respiratory Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. College of Pharmacy, Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System DDS, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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