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Two new compounds from rifamycin resistant mutant strain Streptomyces sp. HS-NF-1046R
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Huan QI1, 3, Zheng MA1, Zheng-lian XUE2, Hai-ning RUAN3, Mei-yue GAO3, Hui ZHANG3, Xiao-ping YU1, *, Ji-dong WANG2, 3, *
Acta Pharmaceutica Sinica | 2019, 54(1) : 117 - 121
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Acta Pharmaceutica Sinica | 2019, 54(1): 117-121
• ORIGINAL ARTICLES •
Two new compounds from rifamycin resistant mutant strain Streptomyces sp. HS-NF-1046R
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Huan QI1, 3, Zheng MA1, Zheng-lian XUE2, Hai-ning RUAN3, Mei-yue GAO3, Hui ZHANG3, Xiao-ping YU1, *, Ji-dong WANG2, 3, *
Affiliations
  • 1. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China
  • 2. Microorganism Fermentation Engineering and Technology Research Center of Anhui Province, Institute of Biologic and Chemical Engineering of Anhui Polytechnic University, Wuhu 241000, China
  • 3. Zhejiang Key Laboratory of Antifungal Drugs, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0974
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Using silica gel column chromatography, gel chromatography and HPLC, we isolated secondary metabolites in fermentation broth of a rifamycin resistant mutation strain Streptomyces sp. HS-NF-1046R. Based on spectroscopic data, the chemical structures of three compounds were identified as 3-hydroxyl-2-N-propionyl-anthranilamide (1), 2, 3-dihydro-8-hydroxy-2, 2-dimethyl quinazolin-4-(1H)-one (2) and 2-aminobenzamide (3). Compounds 1 and 2, as new entities, were evaluated for cytotoxicity against A549, HepG2, HCT-116 and K562 cells using the SRB assay. Compounds 1 and 2 exhibited no cytotoxicity with IC50 over 100 μmol·L-1.

Streptomyces  /  rifamycin resistant screening  /  secondary metabolites  /  structure elucidation
Huan QI, Zheng MA, Zheng-lian XUE, Hai-ning RUAN, Mei-yue GAO, Hui ZHANG, Xiao-ping YU, Ji-dong WANG. Two new compounds from rifamycin resistant mutant strain Streptomyces sp. HS-NF-1046R[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 117 -121 . DOI: 10.16438/j.0513-4870.2018-0974
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Article Info
doi: 10.16438/j.0513-4870.2018-0974
  • Receive Date：2018-10-29
  • Online Date：2026-01-26
  • Published：2019-01-12
Article Data
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History
  • Received：2018-10-29
  • Revised：2018-11-22
Funding
Affiliations
    1. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China
    2. Microorganism Fermentation Engineering and Technology Research Center of Anhui Province, Institute of Biologic and Chemical Engineering of Anhui Polytechnic University, Wuhu 241000, China
    3. Zhejiang Key Laboratory of Antifungal Drugs, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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