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Effect of flufenamic acid on solubility, dissolution and pharmacokinetic behavior of sorafenib in MSNM@SFN
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Yi-fan YIN, Zhuo-yue LI, Hui LI, Yang GUO, Qiang ZHANG, Xuan ZHANG*
Acta Pharmaceutica Sinica | 2019, 54(1) : 48 - 53
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Acta Pharmaceutica Sinica | 2019, 54(1): 48-53
• Special Reports: Promoting the Dissolution of Poorly Soluble Drugs •
Effect of flufenamic acid on solubility, dissolution and pharmacokinetic behavior of sorafenib in MSNM@SFN
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Yi-fan YIN, Zhuo-yue LI, Hui LI, Yang GUO, Qiang ZHANG, Xuan ZHANG*
Affiliations
  • Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0512
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The aim of this study is to investigate the influence of flufenamic acid (FFA) on the solubility, dissolution and bioavailability of sorafenib (SFN) in the combined administration of the MSNM@SFN and FFA. The MSNM@SFN&FFA was prepared by mixing the MSNM@SFN with FFA. The solubility, dissolution and bioavailability of SFN in the MSNM@SFN&FFA complex was investigated in comparison with those of the MSNM@SFN. This study was performed following the National Institutes of Health guidelines for the use of experimental animals; all care and handling of animals were performed with the approval of the Experimental Animal Center of Peking University Health Science Center. The MSNM@SFN&FFA showed no significant influence on the solubility, dissolution and bioavailability of SFN when compared with the MSNM@SFN. These data indicated that FFA had almost no influence on the solubility, dissolution and bioavailability of SFN in the combined administration of MSNM@SFN and FFA, thus providing an experimental foundation for the subsequent formulation research on the combined usage of drugs.

sorafenib loaded nanomatrix drug delivery system  /  flufenamic acid  /  solubility  /  dissolution  /  bioavailability
Yi-fan YIN, Zhuo-yue LI, Hui LI, Yang GUO, Qiang ZHANG, Xuan ZHANG. Effect of flufenamic acid on solubility, dissolution and pharmacokinetic behavior of sorafenib in MSNM@SFN[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 48 -53 . DOI: 10.16438/j.0513-4870.2018-0512
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doi: 10.16438/j.0513-4870.2018-0512
  • Receive Date：2018-05-31
  • Online Date：2026-01-26
  • Published：2019-01-12
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  • Received：2018-05-31
  • Revised：2018-10-10
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    Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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