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Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework
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Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN*, Chuan-bin WU
Acta Pharmaceutica Sinica | 2019, 54(1) : 29 - 35
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Acta Pharmaceutica Sinica | 2019, 54(1): 29-35
• Special Reports: Promoting the Dissolution of Poorly Soluble Drugs •
Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework
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Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN*, Chuan-bin WU
Affiliations
  • School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0826
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The aim of this study is to prepare porous γ-cyclodextrin metal-organic framework (CD-MOF) with good biocompatibility to improve the in vitro release properties of water-insoluble drugs. Different sizes of CD-MOF were obtained by controlling the self-assembly of γ-cyclodextrin and potassium ion and the rate of crystal growth. The poorly water-soluble diflunisal (DIF) was selected as the model drug and loaded into the interior of porous CD-MOF by the impregnation method. The DIF loaded CD-MOF (DIF-MOF) was characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), nitrogen adsorption and desorption, Fourier infrared spectrometer and thermogravimetric analysis. In addition, in vitro cytotoxicity and solubilizing capability of CD-MOF were investigated. It revealed that the obtained CD-MOF was cubic-like with a narrow size distribution and high porosity. Negligible cytotoxicity was found after incubation with RAW264.7 cells. Compared with the pure CD-MOF carrier, the morphology and crystal form of DIF-MOF was not damaged during the drug loading process. Moreover, the solubility and release rate of water-insoluble DIF from the DIF-MOF were significantly increased.

cyclodextrin  /  metal-organic framework  /  solubility  /  water-insoluble drug  /  diflunisal
Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN, Chuan-bin WU. Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 29 -35 . DOI: 10.16438/j.0513-4870.2018-0826
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Year 2019 volume 54 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2018-0826
  • Receive Date：2018-09-10
  • Online Date：2026-01-26
  • Published：2019-01-12
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  • Received：2018-09-10
  • Revised：2018-10-16
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    School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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