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Ciclesonide inhibits Zika virus replication in vitro
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Zhai-wen YAO1, 2, Fang WANG2, 3, Xiu-xiu CHEN1, 2, Chang-bo ZHENG4, Liu-meng YANG2, Si-dong XIONG1, *, Yong-tang ZHENG2, *
Acta Pharmaceutica Sinica | 2020, 55(12) : 2911 - 2917
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Acta Pharmaceutica Sinica | 2020, 55(12): 2911-2917
• Original Articles •
Ciclesonide inhibits Zika virus replication in vitro
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Zhai-wen YAO1, 2, Fang WANG2, 3, Xiu-xiu CHEN1, 2, Chang-bo ZHENG4, Liu-meng YANG2, Si-dong XIONG1, *, Yong-tang ZHENG2, *
Affiliations
  • 1. College of Pharmacy, Soochow University, Suzhou 215021, China
  • 2. Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
  • 3. College of Medicine, Kunming University of Science and Technology, Kunming 650500, China
  • 4. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-0703
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Zika virus (ZIKV) is an emerging mosquito-borne virus that is associated with severe congenital brain malformations in the fetus and Guillain-Barré syndrome in adults. However, there are currently no drugs or preventive vaccines approved for ZIKV infection. Here, ciclesonide has been found significantly against ZIKV activity by plaque and cytotoxicity assays in vitro, and its 50% effective concentration (EC50) to ZIKV SZ01 and MR766 are (0.40±0.22) and (1.59±1.08) μmol·L-1, respectively. Its 50% cytotoxic concentration (CC50) to Vero cells are (64.70±7.33) μmol·L-1; Virus yield reduction and Western blot assays showed that ciclesonide can inhibit replication of ZIKV. In addition, ciclesonide can also inhibit the replication of ZIKV in A549 cells; the results of time of drug addition analysis indicated that ciclesonide mainly acts on the ZIKV RNA synthesis stage. Ciclesonide can also inhibit the internalization of ZIKV. These results indicated that ciclesonide is a potential drug against ZIKV.

ciclesonide  /  glucocorticoid  /  Zika virus  /  inhibition  /  activity
Zhai-wen YAO, Fang WANG, Xiu-xiu CHEN, Chang-bo ZHENG, Liu-meng YANG, Si-dong XIONG, Yong-tang ZHENG. Ciclesonide inhibits Zika virus replication in vitro[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2911 -2917 . DOI: 10.16438/j.0513-4870.2020-0703
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Article Info
doi: 10.16438/j.0513-4870.2020-0703
  • Receive Date：2020-05-09
  • Online Date：2026-01-23
  • Published：2020-12-12
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History
  • Received：2020-05-09
  • Revised：2020-06-24
Funding
Affiliations
    1. College of Pharmacy, Soochow University, Suzhou 215021, China
    2. Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    3. College of Medicine, Kunming University of Science and Technology, Kunming 650500, China
    4. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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