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The molecular mechanism by which the circadian rhythm regulates body metabolism and research progress on intervention in the circadian rhythm by traditional Chinese medicine
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Zhen-shan CHEN1, Yao-wen ZHANG1, Xiao-ming WANG2, 3, 4, Zhen-hua TIAN2, 3, 4, Hai-qiang JIANG2, 3, 4, *, Dong-mei QI2, 3, 4
Acta Pharmaceutica Sinica | 2020, 55(12) : 2818 - 2826
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Acta Pharmaceutica Sinica | 2020, 55(12): 2818-2826
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The molecular mechanism by which the circadian rhythm regulates body metabolism and research progress on intervention in the circadian rhythm by traditional Chinese medicine
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Zhen-shan CHEN1, Yao-wen ZHANG1, Xiao-ming WANG2, 3, 4, Zhen-hua TIAN2, 3, 4, Hai-qiang JIANG2, 3, 4, *, Dong-mei QI2, 3, 4
Affiliations
  • 1. School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 2. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 3. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Jinan 250355, China
  • 4. Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-0690
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Circadian rhythm is an internal regulatory mechanism that allows organisms to adapt to circadian changes in the external environment, and can regulate the body's steady state by affecting the metabolic pathways of multiple organs. When exogenous factors such as eating time, worktime changes, and sleep disturbances cause the body's circadian rhythm to be disrupted, the risk of developing metabolic syndrome is significantly increased. This article explores the relationship between circadian rhythm and body metabolism and summarizes the molecular mechanisms by which circadian rhythm regulates the digestive system, liver and bile acid production, and kidney function. We review research progress on intervention in the circadian rhythm by traditional Chinese medicine and provide a reasonable and valuable basis for follow-up studies on the role of traditional Chinese medicine in research on the molecular mechanisms of regulation of circadian rhythm.

biological clock  /  metabolism  /  molecular mechanism  /  traditional Chinese medicine
Zhen-shan CHEN, Yao-wen ZHANG, Xiao-ming WANG, Zhen-hua TIAN, Hai-qiang JIANG, Dong-mei QI. The molecular mechanism by which the circadian rhythm regulates body metabolism and research progress on intervention in the circadian rhythm by traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2818 -2826 . DOI: 10.16438/j.0513-4870.2020-0690
Year 2020 volume 55 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2020-0690
  • Receive Date:2020-06-05
  • Online Date:2026-01-23
  • Published:2020-12-12
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History
  • Received:2020-06-05
  • Revised:2020-08-11
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Affiliations
    1. School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    3. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Jinan 250355, China
    4. Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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