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The principle of drop-on-powder 3D printing and its application and challenge in solid preparation
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Ru-xin CHEN1, 2, Zeng-ming WANG2, Xiao-lu HAN2, Zhong-cheng LIU1, *, Ai-ping ZHENG2, *
Acta Pharmaceutica Sinica | 2020, 55(12) : 2862 - 2868
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Acta Pharmaceutica Sinica | 2020, 55(12): 2862-2868
• Reviews •
The principle of drop-on-powder 3D printing and its application and challenge in solid preparation
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Ru-xin CHEN1, 2, Zeng-ming WANG2, Xiao-lu HAN2, Zhong-cheng LIU1, *, Ai-ping ZHENG2, *
Affiliations
  • 1. College of Pharmacy, Hebei University, Baoding 071002, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-0575
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3D printing technology has the advantages of accurate spatial distribution, accurate drug release and personalized drug dosage, which can make up for the shortcomings of traditional pharmaceutical technology. In recent years drop-on powder (DoP) 3D printing technology has been widely used in pharmaceutical preparation. Compared with other types of 3D printing technology, it is more simple, flexible and easy to operate. In 2015, Aprecia Pharmaceuticals announced that the US Food and Drug Administration (FDA) approves the launch of its first instant tablet Spritam® (levetiracetam) made with DoP 3D printing. After the first 3D printed medicine was launched, people also saw the unique advantages and broad prospects of DoP 3D printing technology platform in pharmaceutical preparation. This review focuses on the technical principles and key factors of DoP 3D printing, its application in the preparation field and its future development challenges.

3D printing technology  /  drop-on-powder  /  principle  /  solid preparation  /  individualized administration
Ru-xin CHEN, Zeng-ming WANG, Xiao-lu HAN, Zhong-cheng LIU, Ai-ping ZHENG. The principle of drop-on-powder 3D printing and its application and challenge in solid preparation[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2862 -2868 . DOI: 10.16438/j.0513-4870.2020-0575
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Article Info
doi: 10.16438/j.0513-4870.2020-0575
  • Receive Date：2020-04-18
  • Online Date：2026-01-23
  • Published：2020-12-12
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  • Received：2020-04-18
  • Revised：2020-06-05
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Affiliations
    1. College of Pharmacy, Hebei University, Baoding 071002, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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