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Advances in research on mechanisms of diabetic wound healing
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Nuo-qi WANG, Xiu-ying YANG*, Guan-hua DU*
Acta Pharmaceutica Sinica | 2020, 55(12) : 2811 - 2817
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Acta Pharmaceutica Sinica | 2020, 55(12): 2811-2817
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Advances in research on mechanisms of diabetic wound healing
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Nuo-qi WANG, Xiu-ying YANG*, Guan-hua DU*
Affiliations
  • Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-0933
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Wound healing is a complex and highly regulated process to maintaining the skin barrier function. Wounds of diabetic patients are hard or even not healing. Non-healing diabetic foot ulcers can lead to lower-extremity amputations. Diabetic wound healing problem is the main complication that leads to high disability rate of diabetes and can threaten the lives in severe cases. The healing of skin wounds requires the synergy of multiple factors to restore the injured skin to its barrier function. The mechanisms that cause it difficult to heal diabetic wounds are complex, including oxidative stress, chronic inflammation, decreased neovascularization, peripheral neuropathy, and imbalance of extracellular matrix accumulation and remodeling. This review classifies mechanisms of diabetic wound healing and provides a reference for its further research.

diabetes  /  wound healing  /  skin  /  oxidative stress  /  chronic inflammation
Nuo-qi WANG, Xiu-ying YANG, Guan-hua DU. Advances in research on mechanisms of diabetic wound healing[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2811 -2817 . DOI: 10.16438/j.0513-4870.2020-0933
Year 2020 volume 55 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2020-0933
  • Receive Date:2020-06-09
  • Online Date:2026-01-23
  • Published:2020-12-12
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  • Received:2020-06-09
  • Revised:2020-07-09
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    Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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