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Research progress on the abnormal metabolism of macrophages in rheumatoid arthritis pathogenesis
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Yue-ye WANG, Yan CHANG*, Wei WEI*
Acta Pharmaceutica Sinica | 2020, 55(12) : 2827 - 2833
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Acta Pharmaceutica Sinica | 2020, 55(12): 2827-2833
• Reviews •
Research progress on the abnormal metabolism of macrophages in rheumatoid arthritis pathogenesis
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Yue-ye WANG, Yan CHANG*, Wei WEI*
Affiliations
  • Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-0708
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Macrophages play an important role in the pathogenesis of rheumatoid arthritis (RA). Previously, studies have shown that changes in the metabolism of glucose, choline, amino acids and lipids in macrophages of patients with RA can lead to the accumulation of metabolic intermediates which can act as inflammatory signaling molecules to aggravate the inflammation and cause complications. Therefore, a full understanding of the metabolic process of macrophages in RA patients will lay the foundation for macrophage-targeted therapy of RA. In this review, not only the role of macrophage abnormal metabolism in the pathogenesis of RA but also the research progress on macrophage-targeted drugs in RA treatment will be discussed.

macrophage  /  rheumatoid arthritis  /  metabolism  /  drug  /  therapy
Yue-ye WANG, Yan CHANG, Wei WEI. Research progress on the abnormal metabolism of macrophages in rheumatoid arthritis pathogenesis[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2827 -2833 . DOI: 10.16438/j.0513-4870.2020-0708
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Year 2020 volume 55 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2020-0708
  • Receive Date：2020-05-09
  • Online Date：2026-01-23
  • Published：2020-12-12
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  • Received：2020-05-09
  • Revised：2020-07-05
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    Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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