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Determination of the K-value of different types of povidone by microfluidic rheometry and the relationship between K-value and weight-average molecular weight
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Li HU1, 2, Jue WANG1, 2, Hui-min SUN2, Jia-sheng TU1, *
Acta Pharmaceutica Sinica | 2020, 55(10) : 2454 - 2459
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Acta Pharmaceutica Sinica | 2020, 55(10): 2454-2459
• Original Articles •
Determination of the K-value of different types of povidone by microfluidic rheometry and the relationship between K-value and weight-average molecular weight
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Li HU1, 2, Jue WANG1, 2, Hui-min SUN2, Jia-sheng TU1, *
Affiliations
  • 1. Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • 2. NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China
Published: 2020-10-12 doi: 10.16438/j.0513-4870.2020-0722
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K-values of 56 batches of 7 types of povidone were measured by microfluidic rheometry and with a Ubbelohde capillary viscometer. The K-values of the two methods were tested by SPSS software and the results showed that there was no significant difference between the two methods (P > 0.05). Taking K-values measured with the Ubbelohde capillary viscometer (Ku) as the abscissa and K-values measured by microfluidic rheometry (Km) as the ordinate a linear equation was calculated:Km=0.893 9Ku + 4.617 6, R2=0.986 2, with good linearity, indicating that the microfluidic rheometer method can replace the Ubbelohde capillary viscometer in determining K-values of povidone. The microfluidic rheometer method has the benefits of less sample consumption, faster determination, and is more accurate, and it can be used with high-throughput automatic acquisition, which provides a more convenient method for the determination of K-values of different types of povidone. The weight-average molecular weights (Mw) of each type of povidone were measured by gel permeation chromatography-multi angle laser light scattering (GPC-MALLS), and the relationship between Mw and Km was lgMw=-0.000 4 Km2 + 0.072 7 Km + 2.791, R2 =0.990 1. The fitting relationship was good, and Mw could be calculated by Km by the equation.

povidone  /  K-value  /  Ubbelohde capillary viscometer  /  microfluidic rheometer  /  gel permeation chromatography-multi angle laser light scattering  /  weight-average molecular weight
Li HU, Jue WANG, Hui-min SUN, Jia-sheng TU. Determination of the K-value of different types of povidone by microfluidic rheometry and the relationship between K-value and weight-average molecular weight[J]. Acta Pharmaceutica Sinica, 2020 , 55 (10) : 2454 -2459 . DOI: 10.16438/j.0513-4870.2020-0722
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Article Info
doi: 10.16438/j.0513-4870.2020-0722
  • Receive Date：2020-05-10
  • Online Date：2026-01-23
  • Published：2020-10-12
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  • Received：2020-05-10
  • Revised：2020-05-31
Funding
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    1. Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
    2. NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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