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Advances in the study of gut pharmacomicrobiomics
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Yue-mei SUN1, Ya-ting ZHANG2, Juan-hong ZHANG1, Xue LI2, Rong WANG1, 2, *, Wen-bin LI1, *
Acta Pharmaceutica Sinica | 2020, 55(10) : 2314 - 2321
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Acta Pharmaceutica Sinica | 2020, 55(10): 2314-2321
• Reviews •
Advances in the study of gut pharmacomicrobiomics
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Yue-mei SUN1, Ya-ting ZHANG2, Juan-hong ZHANG1, Xue LI2, Rong WANG1, 2, *, Wen-bin LI1, *
Affiliations
  • 1. Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, the 940 th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China
  • 2. College of Pharmacy, Lanzhou University, Lanzhou 730000, China
Published: 2020-10-12 doi: 10.16438/j.0513-4870.2020-0455
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The intestinal flora is a diverse microbial community living in the digestive tract of humans and animals. This microbial community can modify drugs in unpredictable ways, leading to changes in the pharmacokinetics of drugs in vivo and affecting their clinical efficacy. Here we review drug metabolism mediated by intestinal flora from three aspects:prodrug activation, drug inactivation, and toxicity. The effect of the stable hypoxic environment on the composition and quantity of intestinal flora and the effect on drug metabolism are discussed. Understanding the influence of intestinal flora on drug metabolism is not only conducive to individualized medication, but also conducive to rational drug design, allowing us to predict and understand individual drug response and regulate the intestinal microbiome to improve drug efficacy, thus promoting personalized medicine.

intestinal flora  /  pharmacokinetics  /  efficacy  /  plateau hypoxic environment  /  individualized medication
Yue-mei SUN, Ya-ting ZHANG, Juan-hong ZHANG, Xue LI, Rong WANG, Wen-bin LI. Advances in the study of gut pharmacomicrobiomics[J]. Acta Pharmaceutica Sinica, 2020 , 55 (10) : 2314 -2321 . DOI: 10.16438/j.0513-4870.2020-0455
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Year 2020 volume 55 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2020-0455
  • Receive Date：2020-04-01
  • Online Date：2026-01-23
  • Published：2020-10-12
Article Data
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History
  • Received：2020-04-01
  • Revised：2020-05-20
Funding
Affiliations
    1. Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, the 940 th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China
    2. College of Pharmacy, Lanzhou University, Lanzhou 730000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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