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Research progress on the role of Ang/Tie axis in angiogenesis and metastasis
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Cheng QIAN1, Wei-wei ZHENG1, Wei ZOU1, Chun-mei YANG1, Shan ZHANG1, Yuan-yuan WU1, Yin LU1, 2, Ai-yun WANG1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(10) : 2291 - 2297
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Acta Pharmaceutica Sinica | 2020, 55(10): 2291-2297
• Reviews •
Research progress on the role of Ang/Tie axis in angiogenesis and metastasis
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Cheng QIAN1, Wei-wei ZHENG1, Wei ZOU1, Chun-mei YANG1, Shan ZHANG1, Yuan-yuan WU1, Yin LU1, 2, Ai-yun WANG1, 2, *
Affiliations
  • 1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2020-10-12 doi: 10.16438/j.0513-4870.2020-0045
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The tumor contains abundant new vessels, which are unevenly distributed, irregular, and branch-disordered. Angiopoietin (Ang) and tyrosine kinase receptor Tie mediate stable maturation of angiogenesis. Ang1 mainly plays a role in promoting vascular stabilization, and Ang2 is highly expressed in vessels, which makes the structure and function of vessels abnormal. Leaked vessels provide opportunities for invasion and metastasis of circulating tumor cells. Targeting the Ang/Tie axis to correct the abnormal state of vessels and promote its normalization, combined with chemotherapy drugs or immunotherapy, play a synergistic effect against tumors. This article summarizes the role of Ang/Tie axis in tumor angiogenesis and metastasis, and it aims to provide new ideas and strategies for clinical treatment of tumors.

angiopoietin  /  tyrosine kinase receptor  /  angiogenesis  /  tumor metastatic  /  therapeutic strategies
Cheng QIAN, Wei-wei ZHENG, Wei ZOU, Chun-mei YANG, Shan ZHANG, Yuan-yuan WU, Yin LU, Ai-yun WANG. Research progress on the role of Ang/Tie axis in angiogenesis and metastasis[J]. Acta Pharmaceutica Sinica, 2020 , 55 (10) : 2291 -2297 . DOI: 10.16438/j.0513-4870.2020-0045
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Article Info
doi: 10.16438/j.0513-4870.2020-0045
  • Receive Date：2020-01-14
  • Online Date：2026-01-23
  • Published：2020-10-12
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History
  • Received：2020-01-14
  • Revised：2020-02-14
Funding
Affiliations
    1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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