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Derivation of the biogenic pathway and identification of new compounds of Epimedium based on Yinyanghuo as the main metabolite
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Wei-han QIN, Yong YANG, Yan-lei GUO, Qing LI, Xiao-mei ZHANG, Xiang LIU*
Acta Pharmaceutica Sinica | 2020, 55(9) : 2176 - 2181
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Acta Pharmaceutica Sinica | 2020, 55(9): 2176-2181
• Original Articles •
Derivation of the biogenic pathway and identification of new compounds of Epimedium based on Yinyanghuo as the main metabolite
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Wei-han QIN, Yong YANG, Yan-lei GUO, Qing LI, Xiao-mei ZHANG, Xiang LIU*
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  • Chongqing Institute of Traditional Chinese Medicine, Chongqing 400065, China
Published: 2020-09-12 doi: 10.16438/j.0513-4870.2020-0327
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The chemical structures of new components of Epimedium were deduced and verified by combining the secondary metabolism of Epimedium flavonoids with high resolution mass spectrometry. Based on the literature of Epimedium chemistry, the biosynthesis pathway of Yinyanghuo was constructed, and the possible metabolites were deduced. This metabolite information was entered into the PeakView software program and the ions meeting the quality error of less than 5 ppm with correct isotope distribution and containing secondary fragments were taken as the target compounds. Through the use of the software Formula Finder, Mass Calculators, online database (ChemSpider, Metlin, HMDB, etc.) and the fragmentation law of secondary fragments, the chemical structures of 22 metabolites were determined. One new component and eight new compounds were identified in 54 batches of Epimedium samples from 15 varieties by high resolution mass spectrometry. This study avoids the long time and tedious steps of phytochemical separation, saves experimental costs, and provides a new method for the analysis and identification of secondary metabolites with pharmacodynamic activity.

Epimedium  /  secondary metabolism  /  high resolution mass spectrometry  /  Yinyanghuo  /  new compound
Wei-han QIN, Yong YANG, Yan-lei GUO, Qing LI, Xiao-mei ZHANG, Xiang LIU. Derivation of the biogenic pathway and identification of new compounds of Epimedium based on Yinyanghuo as the main metabolite[J]. Acta Pharmaceutica Sinica, 2020 , 55 (9) : 2176 -2181 . DOI: 10.16438/j.0513-4870.2020-0327
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doi: 10.16438/j.0513-4870.2020-0327
  • Receive Date：2020-03-14
  • Online Date：2026-01-23
  • Published：2020-09-12
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  • Received：2020-03-14
  • Revised：2020-04-09
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    Chongqing Institute of Traditional Chinese Medicine, Chongqing 400065, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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