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Advances in understanding the role of sphingosine kinase-2 in tumorigenesis and its inhibitors
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Jin-miao ZHANG1, Qing-jing HAO2, Kai-xuan JIANG2, Li-li LI2, Mao-yu ZHANG2, Jin-xin WANG2, *, Kan YANG1, *
Acta Pharmaceutica Sinica | 2020, 55(9) : 2062 - 2069
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Acta Pharmaceutica Sinica | 2020, 55(9): 2062-2069
• Reviews •
Advances in understanding the role of sphingosine kinase-2 in tumorigenesis and its inhibitors
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Jin-miao ZHANG1, Qing-jing HAO2, Kai-xuan JIANG2, Li-li LI2, Mao-yu ZHANG2, Jin-xin WANG2, *, Kan YANG1, *
Affiliations
  • 1. College of Pharmacy, Hebei University, Hebei Key Laboratory of Drug Analysis and Quality Control, Baoding 071002, China
  • 2. College of Pharmacy, China Pharmaceutical University, Jiangsu Provincial Key Laboratory of Drug Molecular Design and Drug Formation Optimization, Nanjing 211198, China
Published: 2020-09-12 doi: 10.16438/j.0513-4870.2020-0014
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In recent years the role of sphingosine kinase 2 (SphK2), a key enzyme in the sphingolipid pathway, in the process of tumorigenesis has gradually been elucidated. Recent research has shown that SphK2 inhibitors can be used as anticancer drugs alone or in combination with existing drugs to increase the therapeutic sensitivity of drug-resistant tumors. Among them, one selective SphK2 inhibitor, ABC294640, shows excellent oral bioavailability and biodistribution in vivo and has now entered Phase Ⅱ clinical research. Therefore, developing innovative drugs based on SphK2 is of great interest. Herein, we discuss progress in understanding the role of SphK2 in tumorigenesis and review the recent development of inhibitors of SphK2.

sphingosine kinase 2  /  tumor  /  inhibitor  /  combination
Jin-miao ZHANG, Qing-jing HAO, Kai-xuan JIANG, Li-li LI, Mao-yu ZHANG, Jin-xin WANG, Kan YANG. Advances in understanding the role of sphingosine kinase-2 in tumorigenesis and its inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (9) : 2062 -2069 . DOI: 10.16438/j.0513-4870.2020-0014
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Article Info
doi: 10.16438/j.0513-4870.2020-0014
  • Receive Date：2020-01-06
  • Online Date：2026-01-23
  • Published：2020-09-12
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  • Received：2020-01-06
  • Revised：2020-02-24
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Affiliations
    1. College of Pharmacy, Hebei University, Hebei Key Laboratory of Drug Analysis and Quality Control, Baoding 071002, China
    2. College of Pharmacy, China Pharmaceutical University, Jiangsu Provincial Key Laboratory of Drug Molecular Design and Drug Formation Optimization, Nanjing 211198, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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