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Investigation of the anti-renal fibrosis effect of Amygdalus mongolica using metabonomics
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Hai-mei HAO1, Xiao-ye JIA1, Hong-bing ZHOU1, Wan-fu BAI1, Hong CHANG1, *, Song-li SHI1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(9) : 2182 - 2190
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Acta Pharmaceutica Sinica | 2020, 55(9): 2182-2190
• Original Articles •
Investigation of the anti-renal fibrosis effect of Amygdalus mongolica using metabonomics
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Hai-mei HAO1, Xiao-ye JIA1, Hong-bing ZHOU1, Wan-fu BAI1, Hong CHANG1, *, Song-li SHI1, 2, *
Affiliations
  • 1. Department of Pharmacy, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014060, China
  • 2. Institute of Bioactive Substance and Function of Mongolian Medicine and Chinese Materia Medica, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014060, China
Published: 2020-09-12 doi: 10.16438/j.0513-4870.2020-0627
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Metabonomics techniques were used to investigate the mechanism and metabolic pathways of total extract of Amygdalus mongolicus against renal fibrosis in rats. Rats were randomly divided into a model group (MOD), a sham surgery group (SDG), a benazepril hydrochloride-treated group (BHT) and three groups treated with the total extract of Amygdalus mongolicus:low-dose group (TOT-L), middle-dose group (TOT-M) and high-dose group (TOT-H), with 10 rats in each group. The rats were given intragastric administration for 3 weeks and kidney and blood samples were taken. Pharmacodynamic studies and ultra performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-Q-TOF/MS) analysis were used to show that the total extract of Amygdalus mongolicus has an anti-fibrotic effect in rats. Compared with the MOD group, rats in the TOT-L, TOT-M and TOT-H groups showed a reversal in 67, 69, and 70 biomarkers, respectively, and shared 62 biomarkers. Reversal was observed for 7 key biomarkers related to renal fibrosis, including S-adenosy-L-methioninamine, ornithine, diketogulonic acid, and others, and changes in 5 metabolic pathways, including arginine and proline metabolism, pentose and glucuronate interconversions. These results give evidence of the metabolic pathways and the mechanism of action of Amygdalus mongolicus to prevent renal fibrosis in rats. The animal experiments were approved by the Medical Ethics Committee of Baotou Medical College (No. 20190314).

Amygdalus mongolica  /  renal fibrosis  /  metabonomics  /  mechanism of action
Hai-mei HAO, Xiao-ye JIA, Hong-bing ZHOU, Wan-fu BAI, Hong CHANG, Song-li SHI. Investigation of the anti-renal fibrosis effect of Amygdalus mongolica using metabonomics[J]. Acta Pharmaceutica Sinica, 2020 , 55 (9) : 2182 -2190 . DOI: 10.16438/j.0513-4870.2020-0627
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Year 2020 volume 55 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2020-0627
  • Receive Date：2020-04-27
  • Online Date：2026-01-23
  • Published：2020-09-12
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  • Received：2020-04-27
  • Revised：2020-05-24
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Affiliations
    1. Department of Pharmacy, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014060, China
    2. Institute of Bioactive Substance and Function of Mongolian Medicine and Chinese Materia Medica, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014060, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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