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The research progress of PROTACs for breast cancer treatment
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Bao-hua XIE1, Zhi-ye HU1, Wen-tao NING1, Lu YANG2, 3, Hai-bing ZHOU1, 3, *
Acta Pharmaceutica Sinica | 2020, 55(9) : 2053 - 2061
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Acta Pharmaceutica Sinica | 2020, 55(9): 2053-2061
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The research progress of PROTACs for breast cancer treatment
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Bao-hua XIE1, Zhi-ye HU1, Wen-tao NING1, Lu YANG2, 3, Hai-bing ZHOU1, 3, *
Affiliations
  • 1. Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
  • 2. Radiological Molecular Imaging Laboratory, Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
  • 3. The State Key Laboratory of Virology, Wuhan 430072, China
Published: 2020-09-12 doi: 10.16438/j.0513-4870.2020-0340
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Breast cancer is the most common malignant tumor in women worldwide. In breast cancer tumor tissues, a variety of targets related to the occurrence and development of breast cancer have been observed, and many drugs have been used in clinical applications for these targets. However, most of these drugs are small molecule inhibitors. With the long-term use of these drugs, acquired drug resistance often occurs in breast cancer patients. To overcome the drug resistance, the development of more efficient drugs is highly desirable in the treatment of breast cancer. Proteolysis targeting chimera (PROTAC) technology is a new kind of targeted protein degradation technology, which has shown broad prospect of applications in the field of drug development. The use of PROTAC technology to target the degradation of relevant targets in breast cancer has become a feasible strategy for breast cancer treatment.

breast cancer  /  target  /  drug resistance  /  PROTACs
Bao-hua XIE, Zhi-ye HU, Wen-tao NING, Lu YANG, Hai-bing ZHOU. The research progress of PROTACs for breast cancer treatment[J]. Acta Pharmaceutica Sinica, 2020 , 55 (9) : 2053 -2061 . DOI: 10.16438/j.0513-4870.2020-0340
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Article Info
doi: 10.16438/j.0513-4870.2020-0340
  • Receive Date：2020-03-17
  • Online Date：2026-01-23
  • Published：2020-09-12
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  • Received：2020-03-17
  • Revised：2020-04-10
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Affiliations
    1. Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
    2. Radiological Molecular Imaging Laboratory, Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
    3. The State Key Laboratory of Virology, Wuhan 430072, China
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小菇属 Mycena 11 5.26
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红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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