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Research progress on the role of bile acids in regulating glycolipid metabolism
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Heng-cai YU1, 2, Shao-cong HOU1, Bing CUI1, Ping-ping LI1, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1419 - 1430
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Acta Pharmaceutica Sinica | 2020, 55(7): 1419-1430
• Reviews •
Research progress on the role of bile acids in regulating glycolipid metabolism
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Heng-cai YU1, 2, Shao-cong HOU1, Bing CUI1, Ping-ping LI1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0781
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Bile acids (BAs) are increasingly being appreciated as signaling molecules. Studies have shown that BAs regulate glucose and lipid metabolism mainly through the intracellular nuclear receptor farnesoid X receptor (FXR) and the transmembrane G protein-coupled receptor 5 (TGR5). FXR and TGR5 are highly expressed in the intestine. This article summarizes the synthesis, circulation, and regulation of BAs, as well as the effects of BAs on glycolipid metabolism through activation of liver FXR and inhibition or activation of intestinal FXR and TGR5. Furthermore, we illustrate the molecular mechanism of BAs on glycolipid metabolism by the relevant signaling pathways, including small heterodimer partner (SHP), fibroblast growth factor 15/19 (FGF15/19), ceramide and glucagon like peptide-1 (GLP-1). This review may serve as a reference for basic and clinical studies.

bile acid  /  glycolipid metabolism  /  intestine  /  farnesoid X receptor  /  transmembrane G protein-coupled receptor 5
Heng-cai YU, Shao-cong HOU, Bing CUI, Ping-ping LI. Research progress on the role of bile acids in regulating glycolipid metabolism[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1419 -1430 . DOI: 10.16438/j.0513-4870.2020-0781
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Year 2020 volume 55 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2020-0781
  • Receive Date：2020-05-19
  • Online Date：2026-01-21
  • Published：2020-07-12
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History
  • Received：2020-05-19
  • Accepted：2020-06-19
Funding
Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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