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Study of Gq mutations and their inhibitors in uveal melanoma
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Shuo SHI1, Kai ZHU2, Xiao-feng XIONG1, *, Xiao-lei ZHANG1, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1382 - 1392
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Acta Pharmaceutica Sinica | 2020, 55(7): 1382-1392
• Reviews •
Study of Gq mutations and their inhibitors in uveal melanoma
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Shuo SHI1, Kai ZHU2, Xiao-feng XIONG1, *, Xiao-lei ZHANG1, *
Affiliations
  • 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
  • 2. Changchun University of Chinese Medicine, Changchun 130117, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0743
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Uveal melanoma (UM) is one of most common ocular cancers and is extremely malignant; so far there is no effective treatment. Moreover, the survival period is only 2-7 months after metastasis. It has been proven that more than 83% of uveal melanomas harbor mutations in G protein subunit α q (GNAQ) or G protein subunit α 11 (GNA11), among which 95% are a Q209P/L single-site mutation. Q209P/L mutations lead to dysfunction of guanine triphosphatase (GTPase) in the G protein and result in constitutive activation of downstream pathways including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), Ras homologue (Rho)/Rho-associated kinase (Rock)/Yes-associated protein (YAP) and others. Therefore, targeting GNAQ/GNA11 mutations are potential strategies for UM treatment. This review will focus on roles of G protein mutations in UM progression, and the potential therapeutic effects of GNAQ/GNA11 inhibitors, and will provide insights into basic and clinical research on UM treatment.

uveal melanoma  /  G protein  /  GNAQ/GNA11  /  G protein-coupled receptor  /  small molecule
Shuo SHI, Kai ZHU, Xiao-feng XIONG, Xiao-lei ZHANG. Study of Gq mutations and their inhibitors in uveal melanoma[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1382 -1392 . DOI: 10.16438/j.0513-4870.2020-0743
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Article Info
doi: 10.16438/j.0513-4870.2020-0743
  • Receive Date：2020-05-12
  • Online Date：2026-01-21
  • Published：2020-07-12
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  • Received：2020-05-12
  • Accepted：2020-06-04
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    1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
    2. Changchun University of Chinese Medicine, Changchun 130117, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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