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Comparative analysis of chemical constituents of deer hide and deer hide gelatin by "peptidomics-modifications" methods
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Rui LIU1, 2, 3, Yue ZHU1, 3, Yun-feng ZHENG1, 3, Ming ZHAO1, 3, Xun LIU4, Yong HUANG5, Hao-kun XU5, Jin-ao DUAN1, 3, *
Acta Pharmaceutica Sinica | 2020, 55(8) : 1882 - 1888
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Acta Pharmaceutica Sinica | 2020, 55(8): 1882-1888
Comparative analysis of chemical constituents of deer hide and deer hide gelatin by "peptidomics-modifications" methods
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Rui LIU1, 2, 3, Yue ZHU1, 3, Yun-feng ZHENG1, 3, Ming ZHAO1, 3, Xun LIU4, Yong HUANG5, Hao-kun XU5, Jin-ao DUAN1, 3, *
Affiliations
  • 1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
  • 2. Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 4. Suzhou Vocational Health College, Suzhou 215009, China
  • 5. Guizhou Guangjitang Pharmaceutical Co., Ltd., Guiyang 550014, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2020-0081
Outline
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Collagen is the main constituent of gelatinous Chinese medicine, with deer hide gelatin (Cervi Corii Colla, DHG) made from deer hide (DH) through a complex thermal and high-pressure processing procedure. During this procedure some amino acids in collagen undergo hydroxylation and deamidation. In the present study, comparative analysis of proteins and peptides in DH and DHG was carried out using "peptidomics-modifications" methods. Nano-LC-MS/MS was used to analyze proteins and peptides in DH and DHG, and the number and sites of modification were determined as well. The amount of hydroxylation and deamidation that occurred in DHG was significantly greater than that in DH, suggesting that under thermal and high-pressure processing these modifications occurred more frequently on certain amino acids in collagen, and might be correlated with hydrophobicity. The occurrence and mechanism of hydroxylation and deamidation in DH processing procedures should be explored in further research. The present study provides important evidence of the chemical constituents and the correlation of processing procedures with these modifications, and also suggests some investigative ideas for DHG processing optimization and improvement of quality standards.

peptidomics  /  modifications  /  deer hide  /  deer hide gelatin  /  chemical constituent
Rui LIU, Yue ZHU, Yun-feng ZHENG, Ming ZHAO, Xun LIU, Yong HUANG, Hao-kun XU, Jin-ao DUAN. Comparative analysis of chemical constituents of deer hide and deer hide gelatin by "peptidomics-modifications" methods[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1882 -1888 . DOI: 10.16438/j.0513-4870.2020-0081
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Article Info
doi: 10.16438/j.0513-4870.2020-0081
  • Receive Date：2020-01-30
  • Online Date：2026-01-21
  • Published：2020-08-12
Article Data
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History
  • Received：2020-01-30
  • Revised：2020-03-14
Funding
Affiliations
    1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
    2. Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    4. Suzhou Vocational Health College, Suzhou 215009, China
    5. Guizhou Guangjitang Pharmaceutical Co., Ltd., Guiyang 550014, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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