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Quality control of red ginseng based on the ratio of ginsenosides Ro/Re
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Yuan-gui YANG1, Ying-bo YANG1, 3, Zheng-cai JU1, Yan-hai Zhang1, Li YANG1, 2, *, Zheng-tao WANG1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(8) : 1897 - 1902
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Acta Pharmaceutica Sinica | 2020, 55(8): 1897-1902
Quality control of red ginseng based on the ratio of ginsenosides Ro/Re
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Yuan-gui YANG1, Ying-bo YANG1, 3, Zheng-cai JU1, Yan-hai Zhang1, Li YANG1, 2, *, Zheng-tao WANG1, 2, *
Affiliations
  • 1. The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Shanghai R & D Center for Standardization of Chinese Medicines, Shanghai 201203, China
  • 3. Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2020-0132
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Ginsenoside Ro decreased measures of inflammation, aging, oxidants and thrombus formation in a previous study. To measure ginsenoside Ro content in red ginseng from different years, an optimized extraction method was developed to determine ginsenoside Rg1, Re, Rb1 and Ro content by HPLC in 43 batches of red ginseng from different origins, growing years and manufacturers. The results indicate that the best extraction method was to ultrasonify a 1 g sample in 70% methanol for 50 min. The total running time of the optimized gradient was 50 min using a C18 core-shell column and was half the time described in the Chinese Pharmacopoeia, 2015 edition. The separation resolution of all of targeted compounds was greater than 1.6. The peak shape of ginsenoside Ro was optimal when the mobile phase consisted of acetonitrile and water with 0.1% phosphoric acid. The content of ginsenoside Ro was in the range of 0.11% to 0.43%, and the average content was 0.26%, which was higher than that of ginsenoside Rg1 and Re. The ratio of ginsenoside Ro and Re as a threshold could be used to discriminate red ginseng from different growing years; in addition, 100%, 94.4% and 46.6% of red ginseng from six, five and four years exceeded the threshold of 1.3. Our optimized analytical method for characterization of red ginseng is convenient and shortens the assay time.

red ginseng  /  ginsenoside Ro  /  quantitative analysis  /  ginsenoside Ro/Re  /  criterion revised
Yuan-gui YANG, Ying-bo YANG, Zheng-cai JU, Yan-hai Zhang, Li YANG, Zheng-tao WANG. Quality control of red ginseng based on the ratio of ginsenosides Ro/Re[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1897 -1902 . DOI: 10.16438/j.0513-4870.2020-0132
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Article Info
doi: 10.16438/j.0513-4870.2020-0132
  • Receive Date：2020-02-16
  • Online Date：2026-01-21
  • Published：2020-08-12
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History
  • Received：2020-02-16
  • Revised：2020-03-21
Funding
Affiliations
    1. The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Shanghai R & D Center for Standardization of Chinese Medicines, Shanghai 201203, China
    3. Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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