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Research advances in M. Tuberculosis polyketide synthase 13 inhibitors
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Wei DING, Wen-ting ZHAO, Dong-feng ZHANG*
Acta Pharmaceutica Sinica | 2020, 55(8) : 1768 - 1773
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Acta Pharmaceutica Sinica | 2020, 55(8): 1768-1773
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Research advances in M. Tuberculosis polyketide synthase 13 inhibitors
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Wei DING, Wen-ting ZHAO, Dong-feng ZHANG*
Affiliations
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Beijing 100050, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2020-0213
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Polyketide synthase 13 (Pks13) performs a critical role in the final assembly step of mycolic acid synthesis in Mycobacterium tuberculosis. The inhibition of Pks13 can influence the biosynthesis of mycolic acid, which leads to Mycobacterium tuberculosis cell death. Researchers have discovered Pks13 inhibitors with five chemical scaffolds as antituberculosis agents. Herein, we summarize recent advances in the study of Pks13 inhibitors including the process of discovery, the mechanism of action and structure-activity relationships.

M.tuberculosis  /  mycolic acid  /  polyketide synthase 13 inhibitor  /  mechanism of action  /  structure-activity relationship
Wei DING, Wen-ting ZHAO, Dong-feng ZHANG. Research advances in M. Tuberculosis polyketide synthase 13 inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1768 -1773 . DOI: 10.16438/j.0513-4870.2020-0213
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Article Info
doi: 10.16438/j.0513-4870.2020-0213
  • Receive Date：2020-02-29
  • Online Date：2026-01-21
  • Published：2020-08-12
Article Data
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History
  • Received：2020-02-29
  • Accepted：2020-03-17
Funding
Affiliations
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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