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Serum biomarkers and bioinformatics of Alzheimer's disease based on LC-MS/MS proteomics
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Ting-ting XU1, Peng GUO2, Wei ZHANG2, *, Xiao-liang WANG1, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1604 - 1613
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Acta Pharmaceutica Sinica | 2020, 55(7): 1604-1613
• Original Articles •
Serum biomarkers and bioinformatics of Alzheimer's disease based on LC-MS/MS proteomics
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Ting-ting XU1, Peng GUO2, Wei ZHANG2, *, Xiao-liang WANG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Neurology Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0770
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To identify potential serum proteins that might serve as biomarkers for Alzheimer's disease (AD), we performed comparative proteomic profiling of sera from AD and healthy control subjects using label-free LC-MS/MS. Our study identified 387 proteins, 61 of which showed significant changes in the serum of AD patients compared to healthy controls. Gene ontology (GO) enrichment analysis showed that some GO terms related to the pathogenesis of AD were significantly enriched in differentially expressed proteins, including cholesterol and lipid metabolism, inflammation, coagulation and hemostasis processes, and immune responses. Therefore, based on the above results and the consistency of protein content changes in the 8 comparison groups, 18 proteins were selected as candidate biomarkers. Protein-protein interaction results suggest that these 18 proteins can directly or indirectly interact with APP. Therefore, changes in the levels or functions of these proteins may affect Aβ metabolism and participate in the occurrence of AD, and have the potential to become AD blood biomarkers.

Alzheimer's disease  /  biomarker  /  serum  /  label free LC-MS/MS  /  proteomics
Ting-ting XU, Peng GUO, Wei ZHANG, Xiao-liang WANG. Serum biomarkers and bioinformatics of Alzheimer's disease based on LC-MS/MS proteomics[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1604 -1613 . DOI: 10.16438/j.0513-4870.2020-0770
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Article Info
doi: 10.16438/j.0513-4870.2020-0770
  • Receive Date：2020-05-18
  • Online Date：2026-01-21
  • Published：2020-07-12
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  • Received：2020-05-18
  • Revised：2020-06-18
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Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Neurology Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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