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Research progress of P450 in the biosynthesis of bioactive compound of medicinal plants
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Ying MA1, Yuan CAI2, Xiao-jing MA1, Guang-hong CUI1, Jin-fu TANG1, Wen ZENG1, Shui-han ZHANG2, Juan GUO1, *, Lu-qi HUANG1, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1573 - 1589
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Acta Pharmaceutica Sinica | 2020, 55(7): 1573-1589
• Reviews •
Research progress of P450 in the biosynthesis of bioactive compound of medicinal plants
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Ying MA1, Yuan CAI2, Xiao-jing MA1, Guang-hong CUI1, Jin-fu TANG1, Wen ZENG1, Shui-han ZHANG2, Juan GUO1, *, Lu-qi HUANG1, *
Affiliations
  • 1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. Institute of Traditional Chinese Medicine, Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0035
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Most of the active ingredients of herbs are secondary metabolites of plants. Cytochrome P450s (P450s) are hemoglobin-containing monooxygenases encoded by a super-gene family, which play important roles in the metabolic network of plants. This review focuses on the role of P450s on biosynthesis of secondary metabolites such as terpenoids, alkaloids, flavonoids and phenylpropanoids. This will provide references for biosynthesis and regulation of secondary metabolites in medicinal plants.

cytochrome P450  /  medicinal plant  /  secondary metabolite  /  biosynthetic pathway
Ying MA, Yuan CAI, Xiao-jing MA, Guang-hong CUI, Jin-fu TANG, Wen ZENG, Shui-han ZHANG, Juan GUO, Lu-qi HUANG. Research progress of P450 in the biosynthesis of bioactive compound of medicinal plants[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1573 -1589 . DOI: 10.16438/j.0513-4870.2020-0035
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Article Info
doi: 10.16438/j.0513-4870.2020-0035
  • Receive Date：2020-01-10
  • Online Date：2026-01-21
  • Published：2020-07-12
Article Data
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History
  • Received：2020-01-10
  • Revised：2020-06-24
Funding
Affiliations
    1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. Institute of Traditional Chinese Medicine, Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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