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Hetero-biosynthesis of the main bioactive components from medicinal fungus Shiraia bambusiccola
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Ya-long ZHANG1, Le ZHANG1, Jie GAO1, Jian BAI1, Dao-jiang YAN1, Yuan-yuan ZHANG2, You-cai HU1, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1691 - 1698
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Acta Pharmaceutica Sinica | 2020, 55(7): 1691-1698
• Original Articles •
Hetero-biosynthesis of the main bioactive components from medicinal fungus Shiraia bambusiccola
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Ya-long ZHANG1, Le ZHANG1, Jie GAO1, Jian BAI1, Dao-jiang YAN1, Yuan-yuan ZHANG2, You-cai HU1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0698
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Shiraia bambusiccola is an important medicinal fungus in China. Hypocrellins with perylenequinone skeleton are main bioactive components of Shiraia bambusiccola, which are widely used in food, medicine, pesticide and other fields as natural photosensitizers. For example, "hypocrellin ointment" has already been used clinically. As a rare and vulnerable species, wild Shiraia bambusiccola resources are very limited. Due to the complex structure and chanllenge in chemical total synthesis of hypocrellins, it is urgent to find an effective strategy to rationally utilize its medicinal value while protecting the wild resources. In this study, a candidate gene cluster hpc was identified in Shiraia sp. cfcc 84681 based on careful bioinformatic analysis. A heterologous expression system for hpc gene cluster was successfully constructed and a mutant strain with high yield of hypocrellins was obtained, which mainly produced hypocrellin A and isohypocrellin A. The main ingredients in the mutant strain are consistent with that in the wild Shiraia bambusiccola. These results provide a new strategy to solve the shortage of wild Shiraia bambusiccola resources.

medicinal fungus  /  Shiraia bambusiccola  /  hypocrellin  /  hetero-biosynthesis  /  synthetic biology
Ya-long ZHANG, Le ZHANG, Jie GAO, Jian BAI, Dao-jiang YAN, Yuan-yuan ZHANG, You-cai HU. Hetero-biosynthesis of the main bioactive components from medicinal fungus Shiraia bambusiccola[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1691 -1698 . DOI: 10.16438/j.0513-4870.2020-0698
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Year 2020 volume 55 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2020-0698
  • Receive Date：2020-05-08
  • Online Date：2026-01-21
  • Published：2020-07-12
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History
  • Received：2020-05-08
  • Revised：2020-06-06
Funding
Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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