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Scutellaria baicalensis Georgi leaf and tea extracts prolong lifespan and alter the metabolomic aging profile in a Drosophila melanogaster aging model
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Xue FENG1, Yu-zhi ZHOU1, *, Jian-xin CHAI3, Qiang CHEN3, Li GAO1, Guan-hua DU1, 2, Xue-mei QIN1, *
Acta Pharmaceutica Sinica | 2020, 55(6) : 1214 - 1221
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Acta Pharmaceutica Sinica | 2020, 55(6): 1214-1221
• Original Articles •
Scutellaria baicalensis Georgi leaf and tea extracts prolong lifespan and alter the metabolomic aging profile in a Drosophila melanogaster aging model
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Xue FENG1, Yu-zhi ZHOU1, *, Jian-xin CHAI3, Qiang CHEN3, Li GAO1, Guan-hua DU1, 2, Xue-mei QIN1, *
Affiliations
  • 1. Modern Research Center of Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 3. Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi 047100, China
Published: 2020-06-12 doi: 10.16438/j.0513-4870.2019-0884
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The paper aims to study and compare the effects of Scutellaria baicalensis leaves (SLE) and Scutellaria baicalensis tea (STE) water extracts on the lifespan of Drosophila melanogaster, and explore their anti-aging mechanism through metabolomics. Lifespan, food intake and fertility were measured after administering different doses of SLE and STE to a Drosophila natural aging model, and the metabolic profile of Drosophila was analyzed by metabolomics and multivariate statistical methods. The results showed that SLE and STE (1, 3 g·L-1) could significantly prolong the average lifespan, median life and maximum lifespan of male Drosophila, improve the fertility of Drosophila, and had no effect on the food intake. Through metabolomics technology, 14 differential metabolites related to aging were found, involving a total of five metabolic pathways. All differential metabolites were reversed after STE intervention, while 13 differential metabolites were reversed after SLE intervention. The results suggest that SLE and STE can delay aging of Drosophila, and the anti-aging mechanism is related to energy metabolism.

Scutellaria baicalensis Georgi leaf water extract  /  Scutellaria baicalensis Georgi tea water extract  /  Drosophila  /  lifespan  /  aging  /  metabolomics
Xue FENG, Yu-zhi ZHOU, Jian-xin CHAI, Qiang CHEN, Li GAO, Guan-hua DU, Xue-mei QIN. Scutellaria baicalensis Georgi leaf and tea extracts prolong lifespan and alter the metabolomic aging profile in a Drosophila melanogaster aging model[J]. Acta Pharmaceutica Sinica, 2020 , 55 (6) : 1214 -1221 . DOI: 10.16438/j.0513-4870.2019-0884
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Article Info
doi: 10.16438/j.0513-4870.2019-0884
  • Receive Date：2019-12-07
  • Online Date：2026-01-21
  • Published：2020-06-12
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  • Received：2019-12-07
  • Revised：2020-02-26
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Affiliations
    1. Modern Research Center of Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    3. Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi 047100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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