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In situ characterization of structural change and internal particle distributions of soft capsules based on synchrotron radiation X-ray micro computed tomography
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Ting XIONG1, 2, Li WU2, Hui PENG3, Wei QIAN3, Wen-ting WU1, Wei-feng ZHU1, Xian-zhen YIN2, *, Ji-wen ZHANG1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(5) : 1030 - 1034
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Acta Pharmaceutica Sinica | 2020, 55(5): 1030-1034
• Original Articles •
In situ characterization of structural change and internal particle distributions of soft capsules based on synchrotron radiation X-ray micro computed tomography
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Ting XIONG1, 2, Li WU2, Hui PENG3, Wei QIAN3, Wen-ting WU1, Wei-feng ZHU1, Xian-zhen YIN2, *, Ji-wen ZHANG1, 2, *
Affiliations
  • 1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3. By-Health Co., Ltd., Zhuhai 519040, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-0565
Outline
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It is difficult to directly observe the structural transformation inside of soft capsules if their shells are opaque. This study was designed to noninvasively in situ measure the structural characteristics of the soft capsules and internal particle distributions to reveal the intrinsic quality of the soft capsules and develop a new technique for reverse engineering and the physical stability evaluation of the soft capsules. In this research, the CT projection images of soft capsules, namely, propolis soft capsules, were collected via synchrotron radiation X-ray micro computed tomography (SR-μCT). After three-dimensional reconstruction, the structural differences of the soft capsules under long-term test and accelerated test for 6 months were quantitatively analyzed by calculating the three-dimensional structure parameters such as volume, number and distribution of the particles inside and the thickness for the wall of the capsules. There were only a small number of particles evenly distributed in the soft capsules stored under common storage condition without layering. On the other hand, the shell wall of the soft capsule turned thinner locally at the occlusal portion and the particles with strong X-ray absorption were densely distributed at the edge of the capsule wall after the accelerated test. This study revealed that the structural parameters of soft capsules obtained by SR-μCT could be used to evaluate the influence of storage environment on the physical stability of soft capsules. The technology provides a new method for quality control and evaluation for the soft capsules.

synchrotron radiation X-ray micro computed tomography  /  in situ  /  propolis  /  soft capsule  /  structure  /  particle  /  stability
Ting XIONG, Li WU, Hui PENG, Wei QIAN, Wen-ting WU, Wei-feng ZHU, Xian-zhen YIN, Ji-wen ZHANG. In situ characterization of structural change and internal particle distributions of soft capsules based on synchrotron radiation X-ray micro computed tomography[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 1030 -1034 . DOI: 10.16438/j.0513-4870.2019-0565
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Year 2020 volume 55 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2019-0565
  • Receive Date：2019-07-16
  • Online Date：2026-01-21
  • Published：2020-05-12
Article Data
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History
  • Received：2019-07-16
  • Revised：2019-10-08
Funding
Affiliations
    1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3. By-Health Co., Ltd., Zhuhai 519040, China
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表12种不同金属材料的力学参数
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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