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Research advances of glutamine metabolism-related targets in tumor treatment
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Ting ZHANG, Jing LIU, Ya DING*
Acta Pharmaceutica Sinica | 2020, 55(5) : 813 - 820
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Acta Pharmaceutica Sinica | 2020, 55(5): 813-820
• Reviews •
Research advances of glutamine metabolism-related targets in tumor treatment
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Ting ZHANG, Jing LIU, Ya DING*
Affiliations
  • Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-1048
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Metabolic reprogramming is an important feature of tumor cell metabolism. Glutamine, as a conditionally essential amino acid, provides material and energy for cell growth and maintains the redox homeostasis of tumor cells. This article reviews the role of glutamine in tumorigenesis, development and metastasis, discusses the relationship between glutamine and key biomacromolecules, and provides ideas for finding new targets in cancer therapy.

glutamine  /  metabolic reprogramming  /  cancer  /  target  /  therapy
张婷, 刘晶, 丁娅. 谷氨酰胺代谢相关靶点在肿瘤治疗中的研究进展. 药学学报, 2020 , 55 (5) : 813 -820 . DOI: 10.16438/j.0513-4870.2019-1048
Ting ZHANG, Jing LIU, Ya DING. Research advances of glutamine metabolism-related targets in tumor treatment[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 813 -820 . DOI: 10.16438/j.0513-4870.2019-1048
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Year 2020 volume 55 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2019-1048
  • Receive Date：2019-12-21
  • Online Date：2026-01-21
  • Published：2020-05-12
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History
  • Received：2019-12-21
  • Revised：2020-02-21
Funding
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    Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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